Multiscale mechanics of the cervical facet capsular ligament, with particular emphasis on anomalous fiber realignment prior to tissue failure.
Multiscale mechanics of the cervical facet capsular ligament, with particular emphasis on anomalous fiber realignment prior to tissue failure.
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DOI：
10.1007/s10237-017-0949-8
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发表时间：
2018-03
影响因子：
3.5
通讯作者：
Barocas VH
中科院分区：
文献类型：
--
作者：
Zhang S;Zarei V;Winkelstein BA;Barocas VH
小关节囊韧带包裹双侧脊柱小关节，是由于传入神经支配引起疼痛性损伤的常见来源。这些韧带表现出结构的复杂性，这被怀疑有助于实验观察到的宏观应变和微观结构组织损伤之间缺乏共定位。这种韧带的异质性和多尺度性质，加上实验测量其微观力学的挑战，阻碍了理解正常或有害负荷下的感觉机制的能力。因此，基于图像的，特定于主题的，多尺度的有限元模型被构建来预测单轴拉伸拉伸下的人类颈椎关节突囊韧带的力学响应。该模型精确地模拟了所有样品的力-位移响应（R2 = 0.99 ± 0.01），并显示出预测两种不同位移下峰值区域应变的大小和位置的希望。然而，在大组织拉伸下的纤维组织方面，模型和实验之间存在一致性损失，这可能是由于缺乏对组织失效的解释。发现由模型预测的平均纤维拉伸比在实验上表现出异常纤维重新排列的区域中显著高于具有正常重新排列的区域（p <0.002）。微结构异常的发展与预测的纤维水平拉伸相关（p <0.009），但与Logistic回归的最大主应力或最大主应变无关。多尺度模型阐明了一个潜在的力学基础，预测损伤倾向的组织域和宏观韧带拉伸和微观病理生理学之间的关系，在subfailure制度定义。
The facet capsular ligaments encapsulate the bilateral spinal facet joints and are common sources of painful injury due to afferent innervation. These ligaments exhibit architectural complexity, which is suspected to contribute to the experimentally observed lack of co-localization between macroscopic strain and microstructural tissue damage. The heterogeneous and multiscale nature of this ligament, combined with challenges in experimentally measuring its microscale mechanics, hinders the ability to understand sensory mechanisms under normal or injurious loading. Therefore, image-based, subject-specific, multiscale finite-element models were constructed to predict the mechanical responses of the human cervical facet capsular ligament under uniaxial tensile stretch. The models precisely simulated the force-displacement responses for all samples (R2=0.99±0.01) and showed promise in predicting the magnitude and location of peak regional strains at two different displacements. Yet, there was a loss of agreement between the model and experiment in terms of fiber organization at large tissue stretch, possibly due to a lack of accounting for tissue failure. The mean fiber stretch ratio predicted by the models was found to be significantly higher in regions that exhibited anomalous fiber realignment experimentally than in regions with normal realignment (p<0.002). The development of microstructural abnormalities was associated with the predicted fiber-level stretch (p<0.009), but not with the elemental maximum principal stress or maximum principal strain by logistic regression. The multiscale models elucidate a potential mechanical basis for predicting injury-prone tissue domains and for defining the relationships between macroscopic ligament stretch and microscale pathophysiology in the subfailure regime.
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DOI：
10.1115/1.4023411
发表时间：
2013-02
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Hadi MF;Barocas VH
通讯作者：
Barocas VH
影响因子：
25
作者：
Ji, RR;Baba, H;Woolf, CJ
通讯作者：
Woolf, CJ
影响因子：
2.5
作者：
Khalsa, PS;Zhang, C;Hadjiargyrou, M
通讯作者：
Hadjiargyrou, M
影响因子：
2.4
作者：
Liao, HY;Belkoff, SM
通讯作者：
Belkoff, SM
影响因子：
7.4
作者：
Crosby ND;Gilliland TM;Winkelstein BA
通讯作者：
Winkelstein BA