Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs
Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs
复制标题
具有 3D 电子转向、实时空化监测和 3D 图像重建算法的便携式高强度聚焦超声系统：猪的临床前研究
作者：
Jin Woo Choi;Jae Young Lee;Eui Jin Hwang;Inpyeong Hwang;S. Woo;Chang Joo Lee;E. Park;B. Choi
目的：本研究的目的是评估一种新型便携式超声引导高强度聚焦超声（USg-HIFU）系统的安全性和准确性，该系统具有三维（3D）电子转向换能器、同步消融和成像模块、实时空化监测和3D图像重建算法。方法：为了解决换能器的准确性，在水室中使用水听器来评估声场的产生。动物研究还对5头猪进行了单点超声消融体内大腿（n=10）或体积超声消融（n=10）和单点超声消融离体肾脏（n=10）。进行组织学和统计学分析。结果：在水听器研究中，在y轴和z轴距离目标1.0 mm范围内，沿x轴在2.0 mm范围内检测到峰值电压（z轴为超声传播方向，y轴和x轴垂直于超声传播方向）。30次HIFU治疗中有29次成功实现了靶区消融。猪大腿在体研究显示，规划超声图与病理标本的差异很小（宽度0.5-1.1 mm，长度3.0 mm）。在活体大腿和离体肾脏研究中，未观察到邻近组织或声道的异常热损伤。结论：我们的研究表明，这种新的USg-HIFU系统可能是一种安全、准确的消融软组织和被包裹器官的技术。
Purpose: The aim of this study was to evaluate the safety and accuracy of a new portable ultrasonography-guided high-intensity focused ultrasound (USg-HIFU) system with a 3-dimensional (3D) electronic steering transducer, a simultaneous ablation and imaging module, real-time cavitation monitoring, and 3D image reconstruction algorithms. Methods: To address the accuracy of the transducer, hydrophones in a water chamber were used to assess the generation of sonic fields. An animal study was also performed in five pigs by ablating in vivo thighs by single-point sonication (n=10) or volume sonication (n=10) and ex vivo kidneys by single-point sonication (n=10). Histological and statistical analyses were performed. Results: In the hydrophone study, peak voltages were detected within 1.0 mm from the targets on the y- and z-axes and within 2.0-mm intervals along the x-axis (z-axis, direction of ultrasound propagation; y- and x-axes, perpendicular to the direction of ultrasound propagation). Twenty-nine of 30 HIFU sessions successfully created ablations at the target. The in vivo porcine thigh study showed only a small discrepancy (width, 0.5-1.1 mm; length, 3.0 mm) between the planning ultrasonograms and the pathological specimens. Inordinate thermal damage was not observed in the adjacent tissues or sonic pathways in the in vivo thigh and ex vivo kidney studies. Conclusion: Our study suggests that this new USg-HIFU system may be a safe and accurate technique for ablating soft tissues and encapsulated organs.
影响因子：
2.9
作者：
Tung, Yao-Sheng;Choi, James J.;Baseri, Babak;Konofagou, Elisa E.
通讯作者：
Konofagou, Elisa E.