Visual activation of extra-striate cortex in the absence of V1 activation.
Visual activation of extra-striate cortex in the absence of V1 activation.
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DOI：
10.1016/j.neuropsychologia.2010.10.022
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发表时间：
2010-12
期刊：
影响因子：
2.6
通讯作者：
Kennard C
中科院分区：
文献类型：
--
作者：
Bridge H;Hicks SL;Xie J;Okell TW;Mannan S;Alexander I;Cowey A;Kennard C
▶V1灰质T1特征异常，灌注减少。▶损伤局限于灰质，无邻近白质受累。钙化沟的BOLD激活水平急剧降低。▶眼外区对视觉刺激的激活被保留。▶LGN - V1通路变性；LGN和V5/MT之间的差异是完整的。当初级视觉皮层（V1）受损时，有许多替代途径可以将视觉信息从眼睛传递到眼外视觉区。外伤或梗死对视觉皮层的损害通常是单侧的，广泛的，包括灰质和白质束，可破坏其他通往残余视觉功能的途径。我们报告一个不寻常的年轻患者，SBR，他有双侧V1灰质损伤，保留邻近的白质和周围的视觉区域。使用功能性磁共振成像（fMRI），我们发现MT+/V5区域在视觉刺激下被激活，而V1区域没有明显的活性。此外，外侧膝状核（LGN）和V1之间的白质束显示出一些变性，而LGN和MT+/V5之间的白质束与对照组没有差异。此外，双侧损伤的性质表明，残留的视觉能力不是由半球间连接加强引起的。SBR中非常特殊的病变表明，LGN和MT+/V5之间的同侧连接可能在V1受损的情况下对剩余的视觉功能很重要。
▶ Gray matter of V1 shows abnormal T1 characteristics and its perfusion is reduced. ▶ Damage is confined to gray matter with no adjacent white matter involvement. ▶ BOLD activation levels in the calcarine sulcus are drastically reduced. ▶ Activation of extrastriate regions to visual stimulation is preserved. ▶ Pathway between LGN and V1 shows degeneration; between LGN and V5/MT is intact. When the primary visual cortex (V1) is damaged, there are a number of alternative pathways that can carry visual information from the eyes to extrastriate visual areas. Damage to the visual cortex from trauma or infarct is often unilateral, extensive and includes gray matter and white matter tracts, which can disrupt other routes to residual visual function. We report an unusual young patient, SBR, who has bilateral damage to the gray matter of V1, sparing the adjacent white matter and surrounding visual areas. Using functional magnetic resonance imaging (fMRI), we show that area MT+/V5 is activated bilaterally to visual stimulation, while no significant activity could be measured in V1. Additionally, the white matter tracts between the lateral geniculate nucleus (LGN) and V1 appear to show some degeneration, while the tracts between LGN and MT+/V5 do not differ from controls. Furthermore, the bilateral nature of the damage suggests that residual visual capacity does not result from strengthened interhemispheric connections. The very specific lesion in SBR suggests that the ipsilateral connection between LGN and MT+/V5 may be important for residual visual function in the presence of damage to V1.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.8
作者：
Giaschi, D;Jan, JE;Wong, PKH
通讯作者：
Wong, PKH
影响因子：
14.5
作者：
Bridge, Holly;Thomas, Owen;Cowey, Alan
通讯作者：
Cowey, Alan
DOI：
10.1073/pnas.92.13.6122
发表时间：
1995-06-20
影响因子：
11.1
作者：
WEISKRANTZ, L;BARBUR, JL;SAHRAIE, A
通讯作者：
SAHRAIE, A
影响因子：
1.7
作者：
HUMPHREY, NK
通讯作者：
HUMPHREY, NK