Blindsight depends on the lateral geniculate nucleus.
Blindsight depends on the lateral geniculate nucleus.
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初级视觉皮层（V1）的损伤导致视觉体验的丧失。尽管如此，仔细的测试表明，即使在没有视觉意识的情况下，某些视觉引导的行为也会持续存在。支持这种现象的神经回路，通常被称为盲视，仍然不确定。在这里，我们证明了一个因果关系的作用，丘脑外侧膝状体核（LGN）在V1独立的视觉信息处理。通过比较功能磁共振成像和行为的措施，并没有暂时LGN失活，我们评估的贡献LGN的猕猴慢性V1病变的视觉功能。在LGN失活之前，呈现给病变影响的视野（暗点）的高对比度刺激在纹外皮质区V2、V3、V4、V5/MT、FST和LIP中产生显著的V1独立fMRI激活，并且在检测任务中被动物正确定位。然而，可逆失活的LGN在V1-病灶半球功能磁共振成像反应和行为检测被废除。两者合计，这些结果表明，直接LGN预测纹外皮层在盲视的关键功能的贡献，并提出了一个可行的途径介导的快速检测在正常视觉。
Injury to the primary visual cortex (V1) leads to the loss of visual experience. Nonetheless, careful testing shows that certain visually guided behaviors can persist even in the absence of visual awareness. The neural circuits supporting this phenomenon, often termed blindsight, remain uncertain. Here we demonstrate a causal role of the thalamic lateral geniculate nucleus (LGN) in V1-independent processing of visual information. By comparing fMRI and behavioral measures with and without temporary LGN inactivation, we assessed the contribution of the LGN to visual functions of macaque monkeys with chronic V1 lesions. Prior to LGN inactivation, high contrast stimuli presented to the lesion-affected visual field (scotoma) produced significant V1 independent fMRI activation in extrastriate cortical areas V2, V3, V4, V5/MT, FST, and LIP, and were correctly located by the animals in a detection task. However, following reversible inactivation of the LGN in the V1-lesioned hemisphere both fMRI responses and behavioral detection were abolished. Taken together, these results demonstrate a critical functional contribution of the direct LGN projections to extrastriate cortex in blindsight, and suggest a viable pathway mediating fast detection during normal vision.
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影响因子：
25
作者：
Sincich, LC;Park, KF;Horton, JC
通讯作者：
Horton, JC
影响因子：
3.7
作者：
Schmid, Michael C.;Panagiotaropoulos, Theofanis;Smirnakis, Stelios M.
通讯作者：
Smirnakis, Stelios M.
影响因子：
14.5
作者：
WEISKRANTZ, L;WARRINGTON, EK;MARSHALL, J
通讯作者：
MARSHALL, J
影响因子：
3.3
作者：
COWEY, A;STOERIG, P;PERRY, VH
通讯作者：
PERRY, VH
影响因子：
2.5
作者：
MOHLER, CW;WURTZ, RH
通讯作者：
WURTZ, RH