Atherosclerosis and leukocyte-endothelial adhesive interactions are increased following acute myocardial infarction in apolipoprotein E deficient mice.
Atherosclerosis and leukocyte-endothelial adhesive interactions are increased following acute myocardial infarction in apolipoprotein E deficient mice.
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DOI：
10.1016/j.atherosclerosis.2010.06.022
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发表时间：
2010-10
期刊：
影响因子：
5.3
通讯作者：
Eitzman, Daniel T.
中科院分区：
文献类型：
--
作者：
Wright, Andrew P.;Oehman, Miina K.;Hayasaki, Takanori;Luo, Wei;Russo, Hana M.;Guo, Chiao;Eitzman, Daniel T.
目的：探讨心肌梗死(MI)对载脂蛋白E缺陷(ApoE−/−)小鼠动脉粥样硬化进展的影响。结扎冠状动脉左前降支(LAD)建立野生型(WT)小鼠(n=9)和载脂蛋白E−/−小鼠(n=25)心肌梗死模型。与假手术动物相比，MI小鼠在活体显微镜下显示血管内白细胞滚动增加和牢固的粘连，反映了增强的全身白细胞与内皮的相互作用。为了确定心肌梗死是否与加速的动脉粥样硬化有关，在载脂蛋白E−/−小鼠中进行了LAD结扎。术后6周，通过显微解剖和油红O染色对整个动脉树的动脉粥样硬化进行定量。载脂蛋白E−/−心肌梗死小鼠的动脉粥样硬化负担是假手术小鼠的1.6倍。急性心肌梗塞加速了小鼠的动脉粥样硬化形成。这些结果可能与人类心肌梗死后再发缺血性冠状动脉事件的风险增加有关。
To determine the effect of myocardial infarction (MI) on progression of atherosclerosis in apolipoprotein E deficient (ApoE−/−) mice. MI was induced following left anterior descending coronary artery (LAD) ligation in wild-type (WT) (n=9) and ApoE−/−(n=25) mice. Compared to sham-operated animals, MI mice demonstrated increased intravascular leukocyte rolling and firm adhesion by intravital microscopy, reflecting enhanced systemic leukocyte-endothelial interactions. To determine if MI was associated with accelerated atherogenesis, LAD ligation was performed in ApoE−/−mice. Six weeks following surgery, atherosclerosis was quantitated throughout the arterial tree by microdissection and Oil- Red-O staining. There was 1.6-fold greater atherosclerosis burden present in ApoE−/− MI mice compared to sham-operated mice. Acute MI accelerates atherogenesis in mice. These results may be related to the increased risk of recurrent ischemic coronary events following MI in humans.
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影响因子：
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