Enhanced diffusion by binding to the crosslinks of a polymer gel.
Enhanced diffusion by binding to the crosslinks of a polymer gel.
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DOI：
10.1038/s41467-018-06851-5
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发表时间：
2018-10-19
影响因子：
16.6
通讯作者：
Ribbeck K
中科院分区：
文献类型：
--
作者：
Goodrich CP;Brenner MP;Ribbeck K
创造一种选择性凝胶，根据粒子之间的相互作用来过滤粒子，这是纳米技术的一个主要目标，从药物输送到控制组装途径都具有深远的意义。然而，当颗粒大于凝胶的特征网格尺寸时，这是特别困难的，因为这样的颗粒不能被动地通过凝胶。因此，过滤需要相互作用的粒子瞬间重组凝胶的内部结构。虽然在DNA工程等方面取得了重大进展，使得设计具有可编程相互作用的纳米材料成为可能，但尚不清楚这种设计凝胶可以利用什么物理原理来实现选择性渗透性。我们提出了一种平衡机制，其中交联结合动力学受到相互作用粒子的影响，从而增强了粒子的扩散。除了揭示制造选择性凝胶的特定设计规则外，我们的研究结果有可能解释某些生物材料（包括核孔复合物）中选择性渗透性的起源。凝胶通过相互作用过滤粒子是纳米技术的目标；当颗粒大于凝胶的网孔时，这是困难的。在这里，作者提出了一种平衡机制，其中交联的结合动力学受到相互作用的粒子的影响，从而使粒子经历增强的扩散。
Creating a selective gel that filters particles based on their interactions is a major goal of nanotechnology, with far-reaching implications from drug delivery to controlling assembly pathways. However, this is particularly difficult when the particles are larger than the gel’s characteristic mesh size because such particles cannot passively pass through the gel. Thus, filtering requires the interacting particles to transiently reorganize the gel’s internal structure. While significant advances, e.g., in DNA engineering, have enabled the design of nano-materials with programmable interactions, it is not clear what physical principles such a designer gel could exploit to achieve selective permeability. We present an equilibrium mechanism where crosslink binding dynamics are affected by interacting particles such that particle diffusion is enhanced. In addition to revealing specific design rules for manufacturing selective gels, our results have the potential to explain the origin of selective permeability in certain biological materials, including the nuclear pore complex. Gels filtering particles by interactions are a goal of nanotechnology; this is difficult when particles are larger than the mesh of the gel. Here, the authors present an equilibrium mechanism where binding dynamics of crosslinks are affected by interacting particles so that particles experience enhanced diffusion.
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