Diagnostic values of soluble mesothelin-related peptides for malignant pleural mesothelioma: updated meta-analysis.
Diagnostic values of soluble mesothelin-related peptides for malignant pleural mesothelioma: updated meta-analysis.
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DOI：
10.1136/bmjopen-2013-004145
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发表时间：
2014-02-24
期刊：
影响因子：
2.9
通讯作者：
Shi HZ
中科院分区：
文献类型：
--
作者：
Cui A;Jin XG;Zhai K;Tong ZH;Shi HZ
尽管血清和/或胸腔液中可溶性间皮素相关肽（SMRP）（包括间皮素和巨核细胞增强因子）对恶性胸膜间皮瘤（MPM）的诊断价值已被广泛研究，但这些SMRP的确切诊断准确性仍存在争议。本荟萃分析的目的是更新血清中SMRP的总体诊断准确性，并进一步确定胸膜液中SMRP对MPM的诊断准确性。系统回顾和荟萃分析.本次荟萃分析共纳入30篇诊断性研究文章。采用随机效应模型，合并血清和胸腔积液SMRP诊断MPM的灵敏度、特异性和其他准确性指标。使用受试者工作特征曲线总结总体试验性能。血清和胸水的敏感性、特异性、阳性似然比、阴性似然比和诊断OR的汇总估计值分别为0.61、0.87、5.71、0.43和14.43，分别为0.79、0.85、4.78、0.30和19.50。还发现，与间皮素相比，血清中的巨核细胞增强因子对MPM具有上级诊断准确性。血清和胸水SMRP是诊断MPM的有用标志物，诊断准确性相似。SMRP测定的阴性结果不足以排除非MPM，阳性检测结果表明，MPM的诊断可能需要进一步的侵入性诊断步骤。
Although the values of soluble mesothelin-related peptides (SMRPs), including mesothelin and megakaryocyte potentiating factor, in serum and/or pleural fluid for diagnosing malignant pleural mesothelioma (MPM) have been extensively studied, the exact diagnostic accuracy of these SMRPs remains controversial. The purpose of the present meta-analysis is to update the overall diagnostic accuracy of SMRPs in serum and, furthermore, to establish diagnostic accuracy of SMRPs in pleural fluid for MPM. Systematic review and meta-analysis. A total of 30 articles of diagnostic studies were included in the current meta-analysis. Sensitivity, specificity and other measures of accuracy of SMRPs in serum and pleural fluid for the diagnosis of MPM were pooled using random effects models. Summary receiver operating characteristic curves were used to summarise overall test performance. The summary estimates of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic OR were 0.61, 0.87, 5.71, 0.43 and 14.43, respectively, for serum and 0.79, 0.85, 4.78, 0.30 and 19.50, respectively, for pleural fluid. It was also found that megakaryocyte potentiating factor in serum had a superior diagnostic accuracy compared with mesothelin for MPM. SMRPs in both serum and pleural fluid are helpful markers for diagnosing MPM with similar diagnostic accuracy. The negative results of SMRP determinations are not sufficient to exclude non-MPM, and the positive test results indicate that further invasive diagnostic steps might be necessary for the diagnosis of MPM.
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影响因子：
2.7
作者：
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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