Are kinesins required for organelle trafficking in plant cells?
Are kinesins required for organelle trafficking in plant cells?
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DOI：
10.3389/fpls.2012.00170
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发表时间：
2012
影响因子：
5.6
通讯作者：
Cresti M
中科院分区：
文献类型：
--
作者：
Cai G;Cresti M
植物细胞表现出膜结合物质的活跃运动，这在大型细胞中更为明显，但在中等大小的细胞和顶端生长的细胞(如花粉管和根毛)中也很明显。细胞器(如高尔基体、内质网、过氧化体和线粒体)和囊泡的运输是植物细胞生理所必需的，并允许细胞内容物或多或少地均匀分布。众所周知，细胞器的长距离运输基本上依赖于肌动蛋白细丝网络，并由肌球蛋白的酶活性提供动力。然而，一些证据表明，微管和基于微管的运动超家族中的运动蛋白成员可能在细胞器和囊泡的定位和/或短距离运动中发挥作用。在不同细胞(如毛状体和花粉管)、在植物细胞生命周期的特定阶段(例如，在膜质体发育期间)和不同细胞器类别(线粒体、高尔基体和叶绿体)中收集的数据支持了这样的假设，即基于微管的马达可能在细胞器运输中发挥微妙但尚未阐明的作用。在某些情况下，这种功能可以通过与肌动蛋白细丝的合作来实现，根据不同家族的马达与细胞器表面联系的功能合作模式。由于现有的数据并没有提供关于肌动蛋白在细胞器运输中的作用的明确结论，在这里，我们想要辩论这样的假设。
Plant cells exhibit active movement of membrane-bounded materials, which is more pronounced in large cells but is also appreciable in medium-sized cells and in tip-growing cells (such as pollen tubes and root hairs). Trafficking of organelles (such as Golgi bodies, endoplasmic reticulum, peroxisomes, and mitochondria) and vesicles is essential for plant cell physiology and allows a more or less homogeneous distribution of the cell content. It is well established that the long-range trafficking of organelles is dependent essentially on the network of actin filaments and is powered by the enzyme activity of myosins. However, some lines of evidence suggest that microtubules and members of the kinesin microtubule-based motor superfamily might have a role in the positioning and/or short-range movement of cell organelles and vesicles. Data collected in different cells (such as trichomes and pollen tubes), in specific stages of the plant cell life cycle (for example, during phragmoplast development) and for different organelle classes (mitochondria, Golgi bodies, and chloroplasts) encourage the hypothesis that microtubule-based motors might play subtle yet unclarified roles in organelle trafficking. In some cases, this function could be carried out in cooperation with actin filaments according to the model of “functional cooperation” by which motors of different families are associated with the organelle surface. Since available data did not provide an unambiguous conclusion with regard to the role of kinesins in organelle transport, here we want to debate such hypothesis.
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