Quinone oxidoreductase 1 is overexpressed in gastric cancer and associated with outcome of adjuvant chemotherapy and survival.
Quinone oxidoreductase 1 is overexpressed in gastric cancer and associated with outcome of adjuvant chemotherapy and survival.
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醌氧化还原酶 1 在胃癌中过度表达，与辅助化疗和生存的结果相关
DOI：
10.3748/wjg.v27.i22.3085
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发表时间：
2021-06-14
影响因子：
4.3
通讯作者：
Tang XW
中科院分区：
文献类型：
--
作者：
Jiang ZN;Ahmed SMU;Wang QC;Shi HF;Tang XW
奎宁氧化还原酶1 （NQO1）在保护正常细胞免受氧化损伤和亲电攻击中起着至关重要的作用。它在许多实体肿瘤中高度表达，表明它在癌症的发生和发展中起作用。然而，NQO1在胃癌中的作用及其对肿瘤发展和预后的影响尚未得到充分的研究。目的：探讨NQO1蛋白在胃癌组织中表达的临床意义，探讨NQO1作为预后生物标志物和治疗靶点的潜力。在本回顾性研究中，对1995年至2011年间接受治疗的175例胃癌患者的标本进行了NQO1的免疫组织化学分析。探讨NQO1表达与胃癌预后及临床病理参数的相关性。NQO1蛋白过表达率为59.43%（104/175）。NQO1过表达与预后明显较差相关。此外，多因素分析表明，NQO1过表达、肿瘤分期和患者年龄是胃癌预后的重要生物标志物。此外，NQO1过表达与5-氟尿嘧啶（5-FU）辅助化疗的更好反应相关。NQO1过表达与胃癌患者预后明显差、5-FU反应较好相关。这些发现对改善胃癌患者的治疗方法具有重要意义。
Quinine oxidoreductase 1 (NQO1) plays a vital role in protecting normal cells against oxidative damage and electrophilic attack. It is highly expressed in many solid tumors, suggesting a role in cancer development and progression. However, the role of NQO1 in gastric cancer and its effect on cancer development and prognosis have not been fully investigated. To investigate the clinical relevance of NQO1 protein expression in gastric cancer and to explore the potential of NQO1 to serve as a prognostic biomarker and therapeutic target. In this retrospective study, gastric cancer specimens of 175 patients who were treated between 1995 and 2011 were subjected to immunohistochemistry analyses for NQO1. The correlation of NQO1 expression with gastric cancer prognosis and clinical and pathological parameters was investigated. NQO1 protein was overexpressed in 59.43% (104/175) of the analyzed samples. Overexpression of NQO1 was associated with a significantly inferior prognosis. In addition, multivariate analysis suggested that NQO1 overexpression, along with tumor stage and patient age, are prominent prognostic biomarkers for gastric cancer. Moreover, NQO1 overexpression was correlated to a better response to 5-fluorouracil (5-FU)-based adjuvant chemotherapy. NQO1 overexpression is associated with a significantly poor prognosis and better response to 5-FU in patients with gastric cancer. These findings are relevant for improving therapeutic approaches for gastric cancer patients.
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影响因子：
3.6
作者：
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影响因子：
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影响因子：
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作者：
Ji M;Jin A;Sun J;Cui X;Yang Y;Chen L;Lin Z
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DOI：
10.1097/pai.0b013e31802e91d0
发表时间：
2008-01-01
影响因子：
1.6
作者：
Awadallah, Nida S.;Dehn, Donna;Shroyer, Kenneth R.
通讯作者：
Shroyer, Kenneth R.