TNF-alpha and neuropathic pain--a review.
TNF-alpha and neuropathic pain--a review.
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DOI：
10.1186/1742-2094-7-27
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发表时间：
2010-04-16
影响因子：
9.3
通讯作者：
Cahill CM
中科院分区：
文献类型：
--
作者：
Leung L;Cahill CM
肿瘤坏死因子-α是在一个多世纪前发现的，它的已知作用已经从免疫系统内部延伸到神经系统中的一个神经炎症区域。神经病理性疼痛是一种公认的病理性疼痛，其伤害性反应持续到神经或其周围组织的损害消失之后。通常，神经病理性疼痛与刺激相关的强度不成比例地增强(痛觉过敏)或改变形式(过敏性或超常痛觉)。在撰写本文时，关于神经病理性疼痛的病因尚未达成共识--可能的机制可归类为神经系统对伤害性刺激的外周敏化和中枢敏化。基于不同类型的神经损伤(周围神经与脊髓神经、结扎与慢性压迫性损伤)的神经病理性疼痛的动物模型一直暗示着肿瘤坏死因子-α在外周和中枢敏化水平上的关键作用。尽管抗肿瘤坏死因子-α治疗在缓解坐骨神经病理性疼痛的临床试验中缺乏成功，但肿瘤坏死因子-α与其他神经炎性信号系统(如趋化因子和p38MAPK)的复杂联系确实启发了系统方法的视角，为未来治疗神经病理性疼痛的药物开发提供了新的视角。
Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known roles have extended from within the immune system to include a neuro-inflammatory domain in the nervous system. Neuropathic pain is a recognized type of pathological pain where nociceptive responses persist beyond the resolution of damage to the nerve or its surrounding tissue. Very often, neuropathic pain is disproportionately enhanced in intensity (hyperalgesia) or altered in modality (hyperpathia or allodynia) in relation to the stimuli. At time of this writing, there is as yet no common consensus about the etiology of neuropathic pain - possible mechanisms can be categorized into peripheral sensitization and central sensitization of the nervous system in response to the nociceptive stimuli. Animal models of neuropathic pain based on various types of nerve injuries (peripheral versus spinal nerve, ligation versus chronic constrictive injury) have persistently implicated a pivotal role for TNF-α at both peripheral and central levels of sensitization. Despite a lack of success in clinical trials of anti-TNF-α therapy in alleviating the sciatic type of neuropathic pain, the intricate link of TNF-α with other neuro-inflammatory signaling systems (e.g., chemokines and p38 MAPK) has indeed inspired a systems approach perspective for future drug development in treating neuropathic pain.
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影响因子：
6.2
作者：
Bettoni, Isabella;Comelli, Francesca;Costa, Barbara
通讯作者：
Costa, Barbara
DOI：
10.1007/bf01191706
发表时间：
1992-05-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BERGSTEINSDOTTIR, K;KINGSTON, A;JESSEN, KR
通讯作者：
JESSEN, KR
DOI：
10.1097/00005072-199101000-00005
发表时间：
1991-01-01
影响因子：
3.2
作者：
BRUCEGREGORIOS, JH;SOUCY, D;BENSON, N
通讯作者：
BENSON, N
影响因子：
56.9
作者：
Beattie, EC;Stellwagen, D;Malenka, RC
通讯作者：
Malenka, RC
影响因子：
5.3
作者：
Amaya, Fumimasa;Wang, Haibin;Woolf, Clifford J.
通讯作者：
Woolf, Clifford J.