Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.
Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.
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DOI：
10.1016/j.breast.2022.09.007
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发表时间：
2022-12
期刊：
影响因子：
3.9
通讯作者：
de Bock, G. H.
中科院分区：
文献类型：
--
作者：
Bodewes, F. T. H.;van Asselt, A. A.;Dorrius, M. D.;Greuter, M. J. W.;de Bock, G. H.
乳房X线密度是乳腺癌的一个明确的危险因素，具有极其致密的乳腺组织与乳腺癌风险增加一到六倍相关。然而，人们质疑这种增加的风险估计是否适用于当前的乳腺密度分类方法。因此，本研究的目的是根据现有文献进一步调查和阐明乳房X线密度与乳腺癌风险之间的关联。系统地检索了 Medline、Embase 和 Web of Science 自 2013 年以来发表的文章，这些文章使用 BI-RADS 词典第 5 版并纳入了数字乳房 X 线摄影数据。使用随机效应模型将粗略数据和最大混杂因素调整后的数据合并为比值比 (OR)。使用 I2 统计、分层和敏感性分析研究乳腺癌风险的异质性。其中包括九项观察性研究。与分散致密乳腺组织（BI-RADS 密度 B）相比，极其致密乳腺组织（BI-RADS 密度 D）导致乳腺癌风险增加 2.11 倍（95% CI 1.84–2.42）。敏感性分析显示，仅使用调整了年龄和 BMI 的数据时，乳腺癌风险增加了 1.83 倍（95% CI 1.52-2.21）。两个结果均具有统计学显着性且同质性。与一般女性群体中 BI-RADS 密度 B 相比，乳房 X 光检查乳腺密度 BI-RADS D 与乳腺癌风险增加约两倍相关。与之前报道的相比，这是一种新颖且较低的风险估计，可能是由于使用了数字乳房 X 线摄影和 BI-RADS 词典第五版而得到的解释。到目前为止，乳房密度与乳腺癌风险增加一到六倍有关。先前的风险评估基于旧的 BI-RADS 词典和屏幕胶片乳房 X 光检查。我们仅纳入使用数字乳房 X 线摄影和 BI-RADS 词典第五版的研究。乳房密度 D 与乳腺癌风险增加两倍相关。与之前报道的研究相比，这是一个较低的风险估计。
Mammographic density is a well-defined risk factor for breast cancer and having extremely dense breast tissue is associated with a one-to six-fold increased risk of breast cancer. However, it is questioned whether this increased risk estimate is applicable to current breast density classification methods. Therefore, the aim of this study was to further investigate and clarify the association between mammographic density and breast cancer risk based on current literature. Medline, Embase and Web of Science were systematically searched for articles published since 2013, that used BI-RADS lexicon 5th edition and incorporated data on digital mammography. Crude and maximally confounder-adjusted data were pooled in odds ratios (ORs) using random-effects models. Heterogeneity regarding breast cancer risks were investigated using I2 statistic, stratified and sensitivity analyses. Nine observational studies were included. Having extremely dense breast tissue (BI-RADS density D) resulted in a 2.11-fold (95% CI 1.84–2.42) increased breast cancer risk compared to having scattered dense breast tissue (BI-RADS density B). Sensitivity analysis showed that when only using data that had adjusted for age and BMI, the breast cancer risk was 1.83-fold (95% CI 1.52–2.21) increased. Both results were statistically significant and homogenous. Mammographic breast density BI-RADS D is associated with an approximately two-fold increased risk of breast cancer compared to having BI-RADS density B in general population women. This is a novel and lower risk estimate compared to previously reported and might be explained due to the use of digital mammography and BI-RADS lexicon 5th edition. So far, breast density was linked to a one-to sixfold increased breast cancer risk. Prior risk estimates were based on old BI-RADS lexicon and screen-film mammography. We included only studies using digital mammography and BI-RADS lexicon 5th edition. Breast density D is associated with a two-fold increased risk of breast cancer. This is a lower risk estimate compared to previously reported studies.
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影响因子：
5.5
作者：
Freer, Phoebe E.
通讯作者：
Freer, Phoebe E.
影响因子：
6.2
作者：
Duffy, Stephen W.;Tabar, Laszlo;Chen, Tony Hsiu-Hsi
通讯作者：
Chen, Tony Hsiu-Hsi
影响因子：
1.1
作者：
Gemici, Aysegul Akdogan;Bayram, Ersoy;Inci, Ercan
通讯作者：
Inci, Ercan
DOI：
10.1186/bcr3372
发表时间：
2013-01-04
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Vachon CM;Fowler EE;Tiffenberg G;Scott CG;Pankratz VS;Sellers TA;Heine JJ
通讯作者：
Heine JJ
影响因子：
1.9
作者：
Hooley, Regina J.
通讯作者：
Hooley, Regina J.