Advances in Campylobacter biology and implications for biotechnological applications.
Advances in Campylobacter biology and implications for biotechnological applications.
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DOI：
10.1111/j.1751-7915.2009.00118.x
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发表时间：
2010-05
影响因子：
5.7
通讯作者：
Zhang Q
中科院分区：
文献类型：
--
作者：
Jeon B;Muraoka WT;Zhang Q
空肠弯曲菌是一种主要的动物源性食源性病原体，也是人类细菌性胃肠炎的主要原因。在过去的十年里，特别是自第一个C。随着空肠基因组序列的研究，人们在了解这种生物的病理生物学和生理学方面取得了重大进展。显然C.空肠利用复杂的机制在各种动物物种的肠道中有效定植。虽然弯曲杆菌在环境中是脆弱的，并且需要苛刻的生长条件，但它在适应包括胃肠道在内的各种生境方面表现出很大的灵活性。这种高适应性归因于其遗传、代谢和表型多样性的种群结构及其应对各种挑战的能力。与大肠杆菌、沙门氏菌等其他肠道病原体不同，弯曲杆菌无法利用外源葡萄糖，主要依赖氨基酸作为碳源进行分解代谢。弯曲杆菌在抗生素治疗中表现出高度的可变性，并具有真核生物样的双重蛋白糖基化系统，该系统修饰鞭毛和其他具有特定糖结构的表面蛋白。在这篇综述中，我们将总结弯曲杆菌的独特的生物学特性，并讨论了潜在的生物技术方法，可以开发控制这种肠道病原体。
Campylobacter jejuni is a major foodborne pathogen of animal origin and a leading cause of bacterial gastroenteritis in humans. During the past decade, especially since the publication of the first C. jejuni genome sequence, major advances have been made in understanding the pathobiology and physiology of this organism. It is apparent that C. jejuni utilizes sophisticated mechanisms for effective colonization of the intestinal tracts in various animal species. Although Campylobacter is fragile in the environment and requires fastidious growth conditions, it exhibits great flexibility in the adaptation to various habitats including the gastrointestinal tract. This high adaptability is attributable to its genetically, metabolically and phenotypically diverse population structure and its ability to change in response to various challenges. Unlike other enteric pathogens, such as Escherichia coli and Salmonella, Campylobacter is unable to utilize exogenous glucose and mainly depends on the catabolism of amino acids as a carbon source. Campylobacter proves highly mutable in response to antibiotic treatments and possesses eukaryote‐like dual protein glycosylation systems, which modify flagella and other surface proteins with specific sugar structures. In this review we will summarize the distinct biological traits of Campylobacter and discuss the potential biotechnological approaches that can be developed to control this enteric pathogen.
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DOI：
10.1073/pnas.0502040102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Andersen-Nissen, E;Smith, KD;Aderem, A
通讯作者：
Aderem, A
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
4.9
作者：
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通讯作者：
Taylor, DE
影响因子：
11.8
作者：
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通讯作者：
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