Renoprotective effect of low iron diet and its consequence on glomerular hemodynamics.
Renoprotective effect of low iron diet and its consequence on glomerular hemodynamics.
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低铁饮食的肾脏保护作用及其对肾小球血流动力学的影响。
DOI：
10.1038/ki.1991.77
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发表时间：
1991
影响因子：
19.6
通讯作者：
Giuseppe Remuzzi
中科院分区：
文献类型：
--
作者：
Andrea Remuzzi;Stefania Puntorieri;Bruno Brugnetti;Tullio Bertani;Giuseppe Remuzzi
据报道，贫血限制了肾质量减少的大鼠的肾损伤。我们研究了低铁饮食，以减少红细胞压积，尿蛋白排泄和肾小球功能的雄性MWF/ZTM大鼠，自发发展蛋白尿和肾小球硬化的影响。在20周龄时，在喂食标准食物的未治疗大鼠和喂食含低铁（5 mg/kg）的等热量饮食的大鼠中进行微穿刺和肾小球体积测量。另外两组大鼠在35周龄时用于总肾功能和肾小球体积评价。在20周龄时，与对照动物相比，低铁饮食的动物显示出显著（P <0.01）降低的红细胞压积（46 +/- 5% vs. 54 +/- 2%）和蛋白尿（60 +/- 15 vs. 225 +/- 34 mg/24 hr），并且在单肾单位血流动力学中未观察到统计学显著差异。在35周龄时，低铁饮食的大鼠的蛋白尿显著低于年龄匹配的对照组（222 +/- 68 vs. 411 +/- 71 mg/24 hr，P <0.01），肾小球硬化程度较轻（肾小球硬化的平均百分比分别为14 +/- 7%和31 +/-17%，P <0.05）。在20周龄和35周龄时，低铁饮食动物和对照动物的肾小球体积相当。这些数据表明，低铁饮食保护雄性MWF/Ztm大鼠肾小球损伤，肾小球血流动力学和肾小球体积没有显着的影响。
It has been reported that anemia limits renal injury in rats with reduced renal mass. We studied the effect of a low iron diet, given to reduce hematocrit, on urinary protein excretion and glomerular function in male MWF/Ztm rats, which spontaneously develop proteinuria and glomerular sclerosis. At 20 weeks of age, micropuncture and glomerular volume measurements were performed in untreated rats fed standard chow and in rats fed an isocaloric diet with low iron (5 mg/kg) content. Two additional groups of rats were used for total kidney function and glomerular volume evaluation at 35 weeks of age. At 20 weeks of age animals on low iron diet showed significantly (P less than 0.01) reduced hematocrit (46 +/- 5% vs. 54 +/- 2%) and proteinuria (60 +/- 15 vs. 225 +/- 34 mg/24 hr) than control animals, and no statistically significant differences were observed in single nephron hemodynamics. At 35 weeks of age rats on low iron diet had significantly lower proteinuria than age matched controls (222 +/- 68 vs. 411 +/- 71 mg/24 hr, P less than 0.01) and developed less glomerular sclerosis (mean percentage of sclerotic glomeruli was respectively 14 +/- 7% and 31 +/- 17%, P less than 0.05). Glomerular volume was comparable in animals on the low iron diet and in controls both at 20 and 35 weeks of age. These data indicate that low iron diet protected male MWF/Ztm rats against glomerular injury without significant effects on glomerular hemodynamics and on glomerular volume.
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抗高血压药物对肾小球形态的影响。
影响因子：
19.6
作者：
Yoshida,Y;Kawamura,T;Ikoma,M;Fogo,A;Ichikawa,I
通讯作者：
Ichikawa,I
血液粘度对血浆肾素活性和肾血流动力学的影响。
DOI：
10.1152/ajprenal.1986.250.1.f40
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Simchon,S;Chen,RY;Carlin,RD;Fan,FC;Jan,KM;Chien,S
通讯作者：
Chien,S
肾小球肥大和上皮细胞损伤调节大鼠进行性肾小球硬化。
DOI：
--
发表时间：
1989
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Fries,JW;Sandstrom,DJ;Meyer,TW;Rennke,HG
通讯作者：
Rennke,HG
毛细血管网络的微血流动力学。
影响因子：
1.1
作者：
Papenfuss,HD;Gross,JF
通讯作者：
Gross,JF
影响因子：
19.6
作者：
PALLER, MS;HEDLUND, BE;WATERFIELD, R
通讯作者：
WATERFIELD, R