Mechanical and biochemical properties of human articular cartilage in osteoarthritic femoral heads and in autopsy specimens.
Mechanical and biochemical properties of human articular cartilage in osteoarthritic femoral heads and in autopsy specimens.
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骨关节炎股骨头和尸检标本中人类关节软骨的机械和生化特性。
DOI：
10.1302/0301-620x.68b2.3958016
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
D. Chappell
中科院分区：
文献类型：
--
作者：
S. Roberts;B. Weightman;J. Urban;D. Chappell
本文对22例骨关节炎患者的手术股骨头和97例尸检股骨头的关节软骨进行了力学和生化特性的研究。在拉伸和压缩两种情况下，对每个股骨头的天顶和前下方的腕关节进行测试。测量含水量、溶胀能力和蛋白多糖含量，对软骨进行组织学检查，并评估下层骨的密度。55例尸检标本被定义为宏观正常，因为它们在用印度墨水染色时没有表现出进行性纤维化模式;但在该组中观察到与年龄相关的含水量、骨密度和抗张强度的显著变化。在20对宏观上都正常的股骨头中，我们惊讶地发现，同一患者左右两侧的软骨有时非常不同。与正常尸检标本相比，骨关节炎标本的膨胀能力显著增加，蛋白多糖含量降低，力学性能受损，拉伸强度较弱，压缩强度较软。异常尸检标本的值介于骨关节炎和正常组之间。这一异常组的结果表明，在早期骨关节炎中没有蛋白多糖的原发性丢失。
We studied the mechanical and biochemical properties of articular cartilage from 22 osteoarthritic femoral heads obtained at operation and 97 femoral heads obtained at autopsy. Cartilage from the zenith and from the antero-inferior aspect of each head was tested both in tension and in compression. Water content, swelling ability and proteoglycan content were measured, the cartilage was examined histologically and the density of the underlying bone was assessed. Fifty-five of the autopsy specimens were defined as macroscopically normal because they exhibited no progressive fibrillation patterns on staining with Indian ink; but significant changes in water content, bone density and tensile strength related to age were seen in this group. In 20 pairs of femoral heads which were both macroscopically normal, we found, surprisingly, that cartilage from the left and right sides of the same patient was sometimes very different. Compared with the normal autopsy specimens the osteoarthritic specimens had a significantly increased swelling ability, a lower proteoglycan content and impaired mechanical properties, being both weaker in tension and softer in compression. Abnormal autopsy specimens had values intermediate between those of osteoarthritic and normal groups. Results from this abnormal group suggest that there is no primary loss of proteoglycan in early osteoarthritis.
正常和严重骨关节炎人类软骨中的蛋白多糖。
DOI：
10.1042/bj1870781
发表时间：
1980
期刊：
The Biochemical journal
影响因子：
--
作者：
Vasan,N
通讯作者：
Vasan,N
DOI：
10.2106/00004623-198163010-00017
发表时间：
1981-01-01
影响因子：
5.3
作者：
MANKIN, HJ;JOHNSON, ME;LIPPIELLO, L
通讯作者：
LIPPIELLO, L