Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies.
Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies.
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膳食钙摄入量和心血管疾病及所有原因导致的死亡风险：前瞻性队列研究
DOI：
10.1186/s12916-014-0158-6
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发表时间：
2014-09-25
期刊：
影响因子：
9.3
通讯作者：
Yan M
中科院分区：
文献类型：
--
作者：
Wang X;Chen H;Ouyang Y;Liu J;Zhao G;Bao W;Yan M
Considerable controversy exists regarding the association between dietary calcium intake and risk of mortality from cardiovascular disease and all causes. Therefore, we performed a meta-analysis of prospective cohort studies to examine the controversy. We identified relevant studies by searching MEDLINE, Embase, and the Cochrane Library databases between 1 September 2013 and 30 December 2013. Reference lists of relevant articles were also reviewed. Observational prospective studies that reported relative risks and 95% confidence intervals for the association of calcium intake with cardiovascular and all-cause mortality were eligible. Study-specific relative risks were pooled using a random-effects model. In this meta-analysis, 11 prospective studies with 12 independent cohorts, involving 757,304 participants, were eligible. There was evidence of a non-linear association between dietary calcium intake and risk of mortality from cardiovascular disease (P for non-linearity <0.01) and all causes (P for non-linearity <0.01). A dose-response analysis showed a U-shaped relationship between dietary calcium intake and cardiovascular mortality. Intakes that were lower and higher than around 800 mg/day were gradually associated with a higher risk of cardiovascular mortality. For all-cause mortality, we also observed a threshold effect at intakes around 900 mg/day. The risk of all-cause mortality did not decrease further at intakes above 900 mg/day. This meta-analysis of prospective cohort studies suggests that dietary calcium intake is associated with cardiovascular mortality in a U-shaped manner and that high dietary calcium intake (>900 mg/day) is not associated with a decreased risk of all-cause mortality. The online version of this article (doi:10.1186/s12916-014-0158-6) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
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通讯作者：
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影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
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5
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Kaluza, Joanna;Orsini, Nicola;Wolk, Alicja
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Wolk, Alicja
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Ix, Joachim H.;Katz, Ronit;Kestenbaum, Bryan R.;de Boer, Ian H.;Chonchol, Michel;Mukamal, Kenneth J.;Rifkin, Dena;Siscovick, David S.;Sarnak, Mark J.;Shlipak, Michael G.
通讯作者：
Shlipak, Michael G.
影响因子：
10.4
作者：
Kousa A;Havulinna AS;Moltchanova E;Taskinen O;Nikkarinen M;Eriksson J;Karvonen M
通讯作者：
Karvonen M