Fast and strong amplifiers of natural selection.
Fast and strong amplifiers of natural selection.
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DOI：
10.1038/s41467-021-24271-w
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发表时间：
2021-06-29
影响因子：
16.6
通讯作者：
Nowak MA
中科院分区：
文献类型：
--
作者：
Tkadlec J;Pavlogiannis A;Chatterjee K;Nowak MA
选择和随机漂移决定了新突变在种群中固定的概率。众所周知，种群结构会影响进化过程的动态。选择放大器是一种群体结构，与混合良好的群体相比，它增加了有益突变体的固定概率。在过去的15年里，广泛的研究已经产生了被称为强放大器的显着结构，它保证了每一个有益的突变都以很高的概率固定。但是，强大的扩增是以相当大的延迟固定事件为代价的，这可能会减缓进化的整体速度。然而，固定概率和时间之间的精确关系仍然难以捉摸。在这里，我们描述了强放大的减速效应。首先，我们证明了所有强放大器必须至少在一定程度上延迟固定事件。其次，我们构建了强大的放大器，延迟固定事件只有轻微的混合人口相比。因此，我们的研究结果建立了固定概率和时间之间的紧密关系：强放大总是以放缓为代价，但不需要超过边际放缓。群体结构可以影响新突变体的固定概率和固定时间。在这里，Tkadlec等人从数学上证明了增加注视概率的结构必然会减慢注视，但也确定了注视时间减少最少的放大结构。
Selection and random drift determine the probability that novel mutations fixate in a population. Population structure is known to affect the dynamics of the evolutionary process. Amplifiers of selection are population structures that increase the fixation probability of beneficial mutants compared to well-mixed populations. Over the past 15 years, extensive research has produced remarkable structures called strong amplifiers which guarantee that every beneficial mutation fixates with high probability. But strong amplification has come at the cost of considerably delaying the fixation event, which can slow down the overall rate of evolution. However, the precise relationship between fixation probability and time has remained elusive. Here we characterize the slowdown effect of strong amplification. First, we prove that all strong amplifiers must delay the fixation event at least to some extent. Second, we construct strong amplifiers that delay the fixation event only marginally as compared to the well-mixed populations. Our results thus establish a tight relationship between fixation probability and time: Strong amplification always comes at a cost of a slowdown, but more than a marginal slowdown is not needed. Population structure can influence the probability of and time to fixation of new mutants. Here, Tkadlec et al. demonstrate mathematically that structures that increase fixation probability necessarily slow fixation, but also identify amplifying structures with minimal reductions in fixation time.
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影响因子：
1.6
作者：
Hindersin, Laura;Moeller, Marius;Bauer, Benedikt
通讯作者：
Bauer, Benedikt
影响因子：
3.3
作者：
Lang GI;Botstein D;Desai MM
通讯作者：
Desai MM
影响因子：
2.4
作者：
Askari, Marziyeh;Samani, Keivan Aghababaei
通讯作者：
Samani, Keivan Aghababaei
影响因子：
2
作者：
Jamieson-Lane, Alastair;Hauert, Christoph
通讯作者：
Hauert, Christoph
DOI：
10.1098/rsif.2014.0606
发表时间：
2014-10-06
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Hindersin L;Traulsen A
通讯作者：
Traulsen A