The association between physical activity and both incident coronary artery calcification and ankle brachial index progression: the multi-ethnic study of atherosclerosis.
The association between physical activity and both incident coronary artery calcification and ankle brachial index progression: the multi-ethnic study of atherosclerosis.
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DOI：
10.1016/j.atherosclerosis.2013.07.045
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发表时间：
2013-10
期刊：
影响因子：
5.3
通讯作者：
Allison MA
中科院分区：
文献类型：
--
作者：
Delaney JA;Jensky NE;Criqui MH;Whitt-Glover MC;Lima JA;Allison MA
冠状动脉钙化（CAC）和踝肱指数（ABI）都是亚临床动脉粥样硬化疾病的衡量标准。体力活动对这些指标纵向变化的影响仍不清楚。为了评估这一点，我们在多种族动脉粥样硬化研究 (MESA) 中检查了这些措施与自我报告的体力活动之间的关联。在基线时，MESA 参与者没有临床明显的心血管疾病。我们纳入了 ABI 在 0.90 至 1.40 之间的所有参与者 (n=5656)。预测变量基于自我报告的测量结果，并使用典型周体力活动调查评估体力活动，从中计算代谢当量分钟/周活动。我们关注身体活动强度、有意识的锻炼、久坐行为和调节。外周动脉疾病 (PAD) 被定义为 ABI 进展至低于 0.90 的值（给定基线范围为 0.90 至 1.40）。事件 CAC 定义为随访后 CAC 评分 >0 Agatston 单位，基线评分为 0 Agatston 单位。平均年龄为 61 岁，53% 为女性，平均体重指数为 28 kg/m2。调整传统心血管危险因素和社会经济因素后，有意识的锻炼可以预防外周动脉疾病的发生（相对风险 (RR)= 0.85，95% 置信区间 (CI)：0.74 至 0.98）。调整传统心血管危险因素和社会经济因素后，剧烈 PA 与 CAC 事件之间存在显着相关性（RR=0.97，95% CI：0.94 至 1.00）。在基线时患有 CAC 的参与者中，久坐行为与 CAC 量增加之间也存在显着相关性 (Δlog(Agatston 单位 +25)=0.027，95% CI 0.002，0.052）。这些数据表明体力活动/久坐行为与亚临床动脉粥样硬化疾病的两种不同测量指标的进展之间存在关联。
Both coronary artery calcification (CAC) and the ankle brachial index (ABI) are measures of subclinical atherosclerotic disease. The influence of physical activity on the longitudinal change in these measures remains unclear. To assess this we examined the association between these measures and self-reported physical activity in the Multi-Ethnic Study of Atherosclerosis (MESA). At baseline, the MESA participants were free of clinically evident cardiovascular disease. We included all participants with an ABI between 0.90 and 1.40 (n=5656). Predictor variables were based on self-reported measures with physical activity being assessed using the Typical Week Physical Activity Survey from which metabolic equivalent-minutes/week of activity were calculated. We focused on physical activity intensity, intentional exercise, sedentary behavior, and conditioning. Incident peripheral artery disease (PAD) was defined as the progression of ABI to values below 0.90 (given the baseline range of 0.90 to 1.40). Incident CAC was defined as a CAC score >0 Agatston units upon follow up with a baseline score of 0 Agatston units. Mean age was 61 years, 53% were female, and mean body mass index was 28 kg/m2. After adjusting for traditional cardiovascular risk factors and socioeconomic factors, intentional exercise was protective for incident peripheral artery disease (Relative Risk (RR)= 0.85, 95% Confidence Interval (CI): 0.74 to 0.98). After adjusting for traditional cardiovascular risk factors and socioeconomic factors, there was a significant association between vigorous PA and incident CAC (RR=0.97, 95% CI: 0.94 to 1.00). There was also a significant association between sedentary behavior and increased amount of CAC among participants with CAC at baseline (Δlog(Agatston Units +25)=0.027, 95% CI 0.002, 0.052). These data suggest that there is an association between physical activity/sedentary behavior and the progression of two different measures of subclinical atherosclerotic disease.
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影响因子：
120.7
作者：
Fowkes, F. G. R.;Murray, G. D.;Butcher, I.;Heald, C. L.;Lee, R. J.;Chambless, L. E.;Folsom, A. R.;Hirsch, A. T.;Dramaix, M.;deBacker, G.;Wautrecht, J-C.;Kornitzer, M.;Newman, A. B.;Cushman, M.;Sutton-Tyrrell, K.;Lee, A. J.;Price, J. F.;d'Agostino, R. B.;Murabito, J. M.;Norman, P. E.;Jamrozik, K.;Curb, J. D.;Masaki, K. H.;Rodriquez, B. L.;Dekker, J. M.;Bouter, L. M.;Heine, R. J.;Nijpels, G.;Stehouwer, C. D. A.;Ferrucci, L.;McDermott, M. M.;Stoffers, H. E.;Hooi, J. D.;Knottnerus, J. A.;Ogren, M.;Hedblad, B.;Witteman, J. C.;Breteler, M. M. B.;Hunink, M. G. M.;Hofman, A.;Criqui, M. H.;Langer, R. D.;Fronek, A.;Hiatt, W. R.;Hamman, R.;Resnick, H. E.;Guralnik, J.;McDermott, M. M.
通讯作者：
McDermott, M. M.
影响因子：
24
作者：
McDermott, Mary M.;Guralnik, Jack M.;Criqui, Michael H.
通讯作者：
Criqui, Michael H.
影响因子：
2.8
作者：
Gardner, Andrew W.;Clancy, Ryan J.
通讯作者：
Clancy, Ryan J.
影响因子：
7.7
作者：
Ingelsson, Erik;Sullivan, Lisa M.;Vasan, Ramachandran S.
通讯作者：
Vasan, Ramachandran S.
影响因子：
24
作者：
Criqui, Michael H.;McClelland, Robyn L.;McDermott, Mary M.;Allison, Matthew A.;Blumenthal, Roger S.;Aboyans, Victor;Ix, Joachim H.;Burke, Gregory L.;Liu, Kaing;Shea, Steven
通讯作者：
Shea, Steven