SALL4 and SF-1 Are Sensitive and Specific Markers for Distinguishing Granulosa Cell Tumors From Yolk Sac Tumors
SALL4 and SF-1 Are Sensitive and Specific Markers for Distinguishing Granulosa Cell Tumors From Yolk Sac Tumors
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SALL4 和 SF-1 是区分颗粒细胞肿瘤和卵黄囊肿瘤的敏感且特异的标记物
DOI：
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发表时间：
2013
影响因子：
1.2
通讯作者：
Z. Bing
中科院分区：
文献类型：
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作者：
S. Bai;Shi Wei;A. Ziober;Yuan Yao;Z. Bing
颗粒细胞瘤分为幼年型和成年型。当它们呈现“网状”生长模式并含有显著的有丝分裂活性时，可能被误解为卵黄囊肿瘤。本文对27例卵黄囊瘤和24例颗粒细胞瘤进行SALL4和类固醇生成因子-1(SF-1)免疫组织化学染色。两种抗体的核染色均为阳性，染色强度分为阴性、弱、中、强四级。所有卵黄囊肿瘤SALL4阳性(100%)，均为中、重度染色，SF-1阴性(100%)。而颗粒细胞瘤均为SF-1阳性(85%为中-强染色，15%为弱染色)，SALL4为阴性(100%)。差异有统计学意义(P<；.01，t检验)。这一结果表明，这两种标记物可以用来区分这两种处于困境中的肿瘤。
Granulosa cell tumors are classified as juvenile and adult types. They may be misinterpreted as a yolk sac tumor when they exhibit a “reticular” growth pattern and contain prominent mitotic activity. In this study, the authors performed immunohistochemical stains for SALL4 and steroidogenic factor-1 (SF-1) on 27 cases of yolk sac tumors and 24 granulosa cell tumors. Nuclear stains for both antibodies were considered as positive and the intensity of staining was graded as negative, weak, moderate, and strong. All the yolk sac tumors were positive for SALL4 (100%) with moderate to strong grade staining and negative for SF-1 (100%). In contrast, all the granulosa cell tumors were positive for SF-1 (85% moderate to strong grade staining and 15% weak staining) and negative for SALL4 (100%). The difference was significant (P < .01, Student’s t test). This result indicates that these 2 markers could be used to distinguish these 2 tumors in a difficult situation.
DOI：
10.1530/ror.0.0050136
发表时间：
2000-09
期刊：
Reviews of reproduction
影响因子：
--
作者：
Y. Sadovsky;C. Dorn
通讯作者：
Y. Sadovsky;C. Dorn