The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense.
The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense.
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DOI：
10.1146/annurev-immunol-112019-072301
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发表时间：
2021-04-26
影响因子：
29.7
通讯作者：
Oberst A
中科院分区：
文献类型：
--
作者：
Snyder AG;Oberst A
几乎所有的动物细胞都含有进化而来的蛋白质，以触发它们所在细胞的破坏。这些蛋白质的激活通过顺序程序进行，人们花了大量的努力来描述导致细胞程序性死亡(PCD)过程的分子机制。这些努力导致了将细胞凋亡定义为正常发育和组织稳态所需的非免疫性PCD的一种形式，将下垂和坏死性下垂定义为由病原体感染引发的与炎症和免疫激活相关的PCD的形式。虽然这一范例在该领域得到了很好的应用，但最近的许多研究强调了这些程序之间的串扰，挑战了细胞凋亡、上睑下垂和坏死性下垂是具有明确免疫输出的线性途径的观点。在这里，我们讨论了细胞死亡作为一个信号网络的新兴想法，考虑到我们现在观察到的细胞死亡途径之间的联系，以及它们在进化起源中的联系。我们还讨论了病原体对细胞死亡途径的参与和颠覆，以及这些过程的关键免疫学结果。
Nearly all animal cells contain proteins evolved to trigger the destruction of the cell in which they reside. The activation of these proteins occurs via sequential programs, and much effort has been expended in delineating the molecular mechanisms underlying the resulting processes of programmed cell death (PCD). These efforts have led to the definition of apoptosis as a form of nonimmunogenic PCD that is required for normal development and tissue homeostasis, and of pyroptosis and necroptosis as forms of PCD initiated by pathogen infection that are associated with inflammation and immune activation. While this paradigm has served the field well, numerous recent studies have highlighted cross talk between these programs, challenging the idea that apoptosis, pyroptosis, and necroptosis are linear pathways with defined immunological outputs. Here, we discuss the emerging idea of cell death as a signaling network, considering connections between cell death pathways both as we observe them now and in their evolutionary origins. We also discuss the engagement and subversion of cell death pathways by pathogens, as well as the key immunological outcomes of these processes.
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影响因子：
64.5
作者：
Cho YS;Challa S;Moquin D;Genga R;Ray TD;Guildford M;Chan FK
通讯作者：
Chan FK
影响因子：
32.4
作者：
Allen, Irving C.;Scull, Margaret A.;Moore, Chris B.;Holl, Eda K.;McElvania-TeKippe, Erin;Taxman, Debra J.;Guthrie, Elizabeth H.;Pickles, Raymond J.;Ting, Jenny P. -Y.
通讯作者：
Ting, Jenny P. -Y.
DOI：
10.1073/pnas.1616829114
发表时间：
2017-03-28
影响因子：
11.1
作者：
Daley-Bauer, Lisa P.;Roback, Linda;Mocarski, Edward S.
通讯作者：
Mocarski, Edward S.
DOI：
10.1084/jem.20100257
发表时间：
2010-08-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Broz P;Newton K;Lamkanfi M;Mariathasan S;Dixit VM;Monack DM
通讯作者：
Monack DM
影响因子：
5.2
作者：
Batista JH;da Silva Neto JF
通讯作者：
da Silva Neto JF