Chromobacterium violaceum Pathogenicity: Updates and Insights from Genome Sequencing of Novel Chromobacterium Species.
Chromobacterium violaceum Pathogenicity: Updates and Insights from Genome Sequencing of Novel Chromobacterium Species.
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DOI：
10.3389/fmicb.2017.02213
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发表时间：
2017
影响因子：
5.2
通讯作者：
da Silva Neto JF
中科院分区：
文献类型：
--
作者：
Batista JH;da Silva Neto JF
紫色铬杆菌是世界上热带和亚热带地区土壤和水微生物区系中含量丰富的组成部分。多年来，它主要是作为紫罗兰素的生产商和发现群体感应分子的记者而闻名。然而，Vioraceum最近已经成为一种环境条件致病菌的重要模式。它在人类感染和小鼠感染模型中的高毒力涉及几个预测的毒力特征，包括两个III型分泌系统(T3SS)。在这篇文章中，除了提供最新的人类紫罗兰感染临床病例的最新情况外，我们还将重点介绍了解紫罗兰致病分子机制的最新进展。已有研究表明，紫罗兰CPI-1 T3SS在与宿主细胞相互作用过程中起着关键作用。它是分泌效应蛋白所必需的，是天然免疫细胞中NOD样受体卡域包含蛋白4(NLRC4)炎症体识别的激动剂。嗜热性下垂及其释放的肝细胞以供中性粒细胞杀死是清除紫罗兰的关键事件。鉴于T3SSs在Vioraceum毒力中的重要作用，我们利用最近获得的几个铬细菌物种的基因组草稿序列，研究了它们在铬杆菌属中的出现情况。我们的发现表明CPI-1 T3SS在变色杆菌物种中广泛存在，这表明该属对人类具有致病潜力，或者T3SS在变色杆菌物种与其他生物相互作用中扮演了新的角色。
Chromobacterium violaceum is an abundant component of the soil and water microbiota in tropical and subtropical regions around the world. For many years, it was mainly known as a producer of violacein and as a reporter for the discovery of quorum sensing molecules. However, C. violaceum has recently emerged as an important model of an environmental opportunistic pathogen. Its high virulence in human infections and a mouse infection model involves the possession of several predicted virulence traits, including two type III secretion systems (T3SSs). In this article, in addition to providing an update on the new clinical cases of human C. violaceum infections, we will focus on recent advances in understanding the molecular mechanisms regarding C. violaceum pathogenesis. It has been demonstrated that the C. violaceum Cpi-1 T3SS plays a pivotal role in interaction with host cells. It is required for the secretion of effector proteins and is the agonist recognized by the Nod-like receptor CARD domain-containing protein 4 (NLRC4) inflammasome from innate immune cells. Pyroptosis and its release of hepatocytes for killing by neutrophils are key events required for the clearance of C. violaceum. Given the prominent role of T3SSs in C. violaceum virulence, we examine their occurrence in the Chromobacterium genus, taking advantage of several draft genome sequences of Chromobacterium species that have recently become available. Our finding that the Cpi-1 T3SS is widespread among Chromobacterium species points toward the pathogenic potential of this genus for humans or to novel roles of the T3SS in the interaction of Chromobacterium species with other organisms.
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影响因子：
2.4
作者：
Hungria, M;Astolfi, S;Vasconcelos, ATR
通讯作者：
Vasconcelos, ATR
DOI：
10.1073/pnas.1520699113
发表时间：
2016-04-26
影响因子：
11.1
作者：
Du, Juan;Reeves, Analise Z.;Lesser, Cammie F.
通讯作者：
Lesser, Cammie F.
影响因子：
1.1
作者：
Ansari, Shamshul;Paudel, Pramod;Gautam, Rajendra
通讯作者：
Gautam, Rajendra
影响因子：
14.9
作者：
Chen IA;Markowitz VM;Chu K;Palaniappan K;Szeto E;Pillay M;Ratner A;Huang J;Andersen E;Huntemann M;Varghese N;Hadjithomas M;Tennessen K;Nielsen T;Ivanova NN;Kyrpides NC
通讯作者：
Kyrpides NC
DOI：
10.1128/genomea.00081-16
发表时间：
2016-03-01
期刊：
GENOME ANNOUNCEMENTS
影响因子：
--
作者：
Chan, Kok-Gan;Yunos, Nina Yusrina Muhamad
通讯作者：
Yunos, Nina Yusrina Muhamad