Implementation of environmental enrichment after middle age promotes healthy aging.
Implementation of environmental enrichment after middle age promotes healthy aging.
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DOI：
10.18632/aging.101502
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发表时间：
2018-07-20
期刊：
影响因子：
--
通讯作者：
Cao L
中科院分区：
文献类型：
--
作者：
McMurphy T;Huang W;Queen NJ;Ali S;Widstrom KJ;Liu X;Xiao R;Siu JJ;Cao L
随着预期寿命的延长，了解衰老的动态、它们与生活方式因素的相互作用以及与年龄相关疾病过程的联系至关重要。我们在环境丰富（EE）方面的工作，即促进心理健康的居住环境，揭示了一种由脑脂肪轴介导的新型抗癌和抗肥胖表型：幼龄动物的下丘脑-交感神经-脂肪细胞（HSA）轴。在这里，我们研究了中年之后开始进行电子电气工程对健康和寿命的影响。六周的短期 EE 激活了 10 个月大小鼠的 HSA 轴。十二个月的长期 EE 可减少肥胖、改善葡萄糖耐量、降低瘦素水平、增强运动能力并抑制焦虑。除了脂肪重塑之外，EE 还可以减少与年龄相关的肝脏脂肪变性，减少肝脏葡萄糖的产生，并增加肝脏和脂肪组织的葡萄糖摄取，从而有助于改善血糖控制。 EE 诱导的肝脏调节与蛋白激酶 Cε 的抑制有关。此外，EE 下调了大脑、脂肪和肝脏中炎症基因的表达。 18 个月大时开始的 EE 显着改善了血糖控制，并对平均寿命产生了积极影响。这些数据表明，EE 会引起代谢和行为适应，而这些适应是已知可延长健康寿命和寿命的因素所共有的。
With increases in life expectancy, it is vital to understand the dynamics of aging, their interaction with lifestyle factors, and the connections to age-related disease processes. Our work on environmental enrichment (EE), a housing environment boosting mental health, has revealed a novel anticancer and anti-obesity phenotype mediated by a brain-fat axis: the hypothalamic-sympathoneural-adipocyte (HSA) axis in young animals. Here we investigated EE effects on healthspan and lifespan when initiated after middle age. Short-term EE for six weeks activated the HSA axis in 10-month-old mice. Long-term EE for twelve months reduced adiposity, improved glucose tolerance, decreased leptin levels, enhanced motor abilities, and inhibited anxiety. In addition to adipose remodeling, EE decreased age-related liver steatosis, reduced hepatic glucose production, and increased glucose uptake by liver and adipose tissue contributing to the improved glycemic control. The EE-induced liver modulation was associated with a suppression of protein kinase Cε. Moreover, EE down-regulated the expression of inflammatory genes in the brain, adipose, and liver. EE initiated at 18-month of age significantly improved glycemic control and showed a trend of positive impact on mean lifespan. These data suggest that EE induces metabolic and behavioral adaptations that are shared by factors known to increase healthspan and lifespan.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
3.3
作者：
Goldberg, N. R. S.;Haack, A. K.;Meshul, C. K.
通讯作者：
Meshul, C. K.
影响因子：
11.4
作者：
Giblin, William;Skinner, Mary E.;Lombard, David B.
通讯作者：
Lombard, David B.
DOI：
10.1073/pnas.0308291101
发表时间：
2004-04-27
影响因子：
11.1
作者：
Fontana, L;Meyer, TE;Holloszy, JO
通讯作者：
Holloszy, JO