Determinants of COVID-19 disease severity in patients with cancer.
Determinants of COVID-19 disease severity in patients with cancer.
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DOI：
10.1038/s41591-020-0979-0
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发表时间：
2020-08
期刊：
影响因子：
82.9
通讯作者：
Kamboj M
中科院分区：
文献类型：
--
作者：
Robilotti EV;Babady NE;Mead PA;Rolling T;Perez-Johnston R;Bernardes M;Bogler Y;Caldararo M;Figueroa CJ;Glickman MS;Joanow A;Kaltsas A;Lee YJ;Lucca A;Mariano A;Morjaria S;Nawar T;Papanicolaou GA;Predmore J;Redelman-Sidi G;Schmidt E;Seo SK;Sepkowitz K;Shah MK;Wolchok JD;Hohl TM;Taur Y;Kamboj M
截至2020年4月10日，纽约州有180，458例SARS-CoV-2病例和9385例死亡报告。癌症患者占死亡人数的8.4%。来自中国和意大利的基于人群的研究表明，癌症患者的COVID-19死亡率较高，尽管对于癌症及其治疗的哪些方面会导致严重COVID-19疾病的风险存在知识缺口。这些信息对于平衡减少SARS-CoV-2暴露和癌症治疗持续性的竞争性安全考虑至关重要。从2020年3月10日至4月7日，Memorial Sloan Kettering癌症中心诊断出423例有症状的COVID-19疾病（来自总共2035名接受测试的癌症患者）。其中，40%因COVID-19疾病住院，20%出现严重呼吸道疾病（包括9%需要机械通气），12%在30天内死亡。年龄>65岁和免疫检查点抑制剂（ICI）治疗是住院和严重疾病的预测因素，而接受化疗和大手术则不是。总体而言，癌症患者的COVID-19疾病的特点是住院率高和后果严重。在我们的研究中观察到的ICI和COVID-19结果之间的关联需要在肿瘤特异性队列中进一步研究。
New York State had 180,458 cases of SARS-CoV-2 and 9385 reported deaths as of April 10th, 2020. Patients with cancer comprised 8.4% of deceased individuals. Population-based studies from China and Italy suggested a higher COVID-19 death rate in patients with cancer, although there is a knowledge gap as to which aspects of cancer and its treatment confer risk of severe COVID-19 disease. This information is critical to balance the competing safety considerations of reducing SARS-CoV-2 exposure and cancer treatment continuation. From March 10th to April 7th, 2020, 423 cases of symptomatic COVID-19 illness were diagnosed at Memorial Sloan Kettering Cancer Center (from a total of 2035 cancer patients tested). Of these, 40% were hospitalized for COVID-19 illness, 20% developed severe respiratory illness, (including 9% who required mechanical ventilation), and 12% died within 30 days. Age >65 years and treatment with immune checkpoint inhibitors (ICI) were predictors for hospitalization and severe disease, while receipt of chemotherapy and major surgery were not. Overall, COVID-19 illness in cancer patients is marked by substantial rates of hospitalization and severe outcomes. The association observed between ICI and COVID-19 outcomes in our study will need further interrogation in tumor-specific cohorts.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
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作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
28.2
作者：
Dai, Mengyuan;Liu, Dianbo;Cai, Hongbing
通讯作者：
Cai, Hongbing
影响因子：
28.2
作者：
Luo, Jia;Rizvi, Hira;Hellmann, Matthew D.
通讯作者：
Hellmann, Matthew D.
影响因子：
33.9
作者：
Chow, Nancy;Fleming-Dutra, Katherine;Ussery, Emily
通讯作者：
Ussery, Emily
DOI：
10.15585/mmwr.mm6915e4
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
CDC COVID-19 Response Team
通讯作者：
CDC COVID-19 Response Team