Mapping vocalization-related immediate early gene expression in echolocating bats.
Mapping vocalization-related immediate early gene expression in echolocating bats.
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DOI：
10.1016/j.bbr.2011.06.023
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发表时间：
2011-10-31
影响因子：
2.7
通讯作者：
Smotherman, Michael S.
中科院分区：
文献类型：
--
作者：
Schwartz, Christine P.;Smotherman, Michael S.
最近对灵长类动物、鲸目动物、蝙蝠和啮齿动物自发发声的研究表明，这些动物拥有有限但有意义的能力来操纵它们发声的时间和声音结构，然而哺乳动物中即使是最简单的发声调制形式的神经基础仍然未知。回声定位蝙蝠快速而常规地操纵它们发出发声的声学结构，以提高回声定位效率，反映出对发声运动路径的认知控制，而不是边缘控制。在这项研究中，我们使用免疫组织化学定位即刻早期基因(c-fos)的表达来定位自发回声定位静止的墨西哥无尾蝙蝠的大脑中的神经活动。我们的结果支持目前主要通过微刺激研究获得的发声控制模型，但也为两个新的区域--尾状背外侧核和丘脑内侧核--的贡献提供了证据，这两个新区域共同表明纹状体丘脑反馈环可能参与了回声定位脉冲产生的控制。此外，我们还发现了动机途径的证据，包括外侧缰核、黑质致密部和中缝核团。这些数据为哺乳动物发声在哪里以及如何受到感觉、上下文和动机线索的调节提供了新的见解。
Recent studies of spontaneously vocalizing primates, cetaceans, bats and rodents suggests these animals possess a limited but meaningful capacity to manipulate the timing and acoustic structure of their vocalizations, yet the neural substrate for even the simplest forms of vocal modulation in mammals remains unknown. Echolocating bats rapidly and routinely manipulate the acoustic structure of their outgoing vocalizations to improve echolocation efficiency, reflecting cognitive rather than limbic control of the vocal motor pathways. In this study, we used immunohistochemical localization of immediate early gene (c-fos) expression to map neural activity in the brains of spontaneously echolocating stationary Mexican free-tailed bats. Our results support the current model of vocal control obtained largely through microstimulation studies, but also provide evidence for the contributions of two novel regions, the dorsolateral caudate nucleus and mediodorsal thalamic nucleus, which together suggest a striatothalamic feedback loop may be involved in the control of echolocation pulse production. Additionally, we found evidence of a motivation pathway, including the lateral habenula, substantia nigra pars compacta, and raphe nuclei. These data provide novel insights into where and how mammalian vocalizations may be regulated by sensory, contextual and motivational cues.
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DOI：
10.1098/rspb.1998.0286
发表时间：
1998-02-07
影响因子：
4.7
作者：
Boughman, JW
通讯作者：
Boughman, JW
影响因子：
1.7
作者：
ESSER, KH
通讯作者：
ESSER, KH
DOI：
10.1007/s00359-006-0205-7
发表时间：
2007-04-01
影响因子：
2.1
作者：
Egnor, S. E. Roian;Wickelgren, Jeanette Graham;Hauser, Marc D.
通讯作者：
Hauser, Marc D.
影响因子：
3.7
作者：
Bohn KM;Schmidt-French B;Schwartz C;Smotherman M;Pollak GD
通讯作者：
Pollak GD
影响因子：
2.4
作者：
Egnor, S. E. Roian;Hauser, Marc D.
通讯作者：
Hauser, Marc D.