The Indispensable Roles of Microglia and Astrocytes during Brain Development.
The Indispensable Roles of Microglia and Astrocytes during Brain Development.
复制标题
DOI：
10.3389/fnhum.2016.00566
复制
发表时间：
2016
影响因子：
2.9
通讯作者：
Hol EM
中科院分区：
文献类型：
--
作者：
Reemst K;Noctor SC;Lucassen PJ;Hol EM
神经胶质细胞在发育过程中和成年大脑中对大脑功能至关重要。在这里，我们讨论了小胶质细胞和星形胶质细胞的各种作用，以及它们在大脑发育过程中的相互作用。虽然这两种细胞在起源和功能上根本不同，但它们通常影响相同的发育过程，例如神经元/胶质细胞生成、血管生成、轴突生长、突触发生和突触修剪。由于它们在这些过程中的重要指导作用，小胶质细胞或星形胶质细胞在大脑发育过程中的功能障碍可能导致神经发育障碍，甚至可能导致迟发性神经病理学。更好地了解小胶质细胞和星形胶质细胞的起源，分化过程和发育功能将有助于充分了解它们在发育中以及在成人大脑中，在健康和疾病中的作用。
Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development. Although both cells are fundamentally different in origin and function, they often affect the same developmental processes such as neuro-/gliogenesis, angiogenesis, axonal outgrowth, synaptogenesis and synaptic pruning. Due to their important instructive roles in these processes, dysfunction of microglia or astrocytes during brain development could contribute to neurodevelopmental disorders and potentially even late-onset neuropathology. A better understanding of the origin, differentiation process and developmental functions of microglia and astrocytes will help to fully appreciate their role both in the developing as well as in the adult brain, in health and disease.
登录
查看更多内容
影响因子：
25
作者：
Ballas, Nurit;Lioy, Daniel T.;Grunseich, Christopher;Mandel, Gail
通讯作者：
Mandel, Gail
影响因子：
16.6
作者：
Arno, Benedetta;Grassivaro, Francesca;Muzio, Luca
通讯作者：
Muzio, Luca
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana
影响因子：
3.8
作者：
Alvarez-Buylla, A;Seri, B;Doetsch, F
通讯作者：
Doetsch, F
影响因子：
82.9
作者：
ALON, T;HEMO, I;KESHET, E
通讯作者：
KESHET, E