Effects of age on psychophysical measures of auditory temporal processing and speech reception at low and high levels.
Effects of age on psychophysical measures of auditory temporal processing and speech reception at low and high levels.
复制标题
年龄对低、高水平听觉时间加工和言语接受心理物理测量的影响。
DOI：
10.1016/j.heares.2020.108117
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发表时间：
2021-03
期刊：
影响因子：
2.8
通讯作者：
Plack CJ
中科院分区：
文献类型：
--
作者：
Carcagno S;Plack CJ
我们几乎没有发现在高声音水平下与年龄相关的听力下降更大的证据。与年龄相关的时间处理能力下降与听力损失无关。没有证据表明年龄相关的语言接收缺陷独立于听力损失。噪声相关的耳蜗突触病（CS）已被证明发生在啮齿动物与最小的噪声暴露，并已被假设在人类年龄相关的听力下降中发挥关键作用。目前尚不清楚年龄相关的CS在人类中发生的程度，以及它如何影响噪声中阈上声音和语音的编码。由于在啮齿动物CS主要影响低和中等自发率（L/M-SR）的神经纤维覆盖中高水平的速率水平的功能，它应该会导致更大的赤字在处理的声音在高比低刺激水平。在这项横断面研究中，102名听众在不同年龄段（34名年轻人，34名中年人，34名老年人）的表现进行了评估，在一组心理物理时间处理和语音接收噪声测试在低，高刺激水平。混合效应多元回归模型被用来估计年龄的影响，同时偏出听力阈值，终身噪声暴露，认知能力（评估额外的测试），和音乐经验的影响。年龄与几项测试中的表现缺陷独立相关。然而，在13个测试中，只有一个测试的年龄效应在高刺激水平下比低刺激水平下明显更大。总的来说，这些结果并没有提供太多的证据表明，年龄相关的CS，在某种程度上，它可能会发生在人类根据啮齿动物模型的更大的L/M-SR突触损失，有实质性的影响心理物理措施的听觉时间处理或语音接收噪声。
We found little evidence of greater age-related hearing declines at high sound levels. There are age-related temporal-processing declines independent of hearing loss. No evidence of age-related speech-reception deficits independent of hearing loss. Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. It is not known to what extent age-related CS occurs in humans, and how it affects the coding of supra-threshold sounds and speech in noise. Because in rodents CS affects mainly low- and medium-spontaneous rate (L/M-SR) auditory-nerve fibers with rate-level functions covering medium-high levels, it should lead to greater deficits in the processing of sounds at high than at low stimulus levels. In this cross-sectional study the performance of 102 listeners across the age range (34 young, 34 middle-aged, 34 older) was assessed in a set of psychophysical temporal processing and speech reception in noise tests at both low, and high stimulus levels. Mixed-effect multiple regression models were used to estimate the effects of age while partialing out effects of audiometric thresholds, lifetime noise exposure, cognitive abilities (assessed with additional tests), and musical experience. Age was independently associated with performance deficits on several tests. However, only for one out of 13 tests were age effects credibly larger at the high compared to the low stimulus level. Overall these results do not provide much evidence that age-related CS, to the extent to which it may occur in humans according to the rodent model of greater L/M-SR synaptic loss, has substantial effects on psychophysical measures of auditory temporal processing or on speech reception in noise.
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影响因子：
3
作者：
Bharadwaj HM;Verhulst S;Shaheen L;Liberman MC;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG
影响因子：
2.8
作者：
Clinard CG;Tremblay KL;Krishnan AR
通讯作者：
Krishnan AR
影响因子：
2.4
作者：
Bolia, RS;Nelson, WT;Simpson, BD
通讯作者：
Simpson, BD
影响因子：
2.4
作者：
Carcagno, Samuele;Lakhani, Saday;Plack, Christopher J.
通讯作者：
Plack, Christopher J.
影响因子：
4.2
作者：
FRIEDRICH, RJ
通讯作者：
FRIEDRICH, RJ