The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.
The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.
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DOI：
10.1053/j.gastro.2011.03.011
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发表时间：
2011-06
期刊：
影响因子：
29.4
通讯作者：
Mayer EA
中科院分区：
文献类型：
--
作者：
Kilpatrick LA;Labus JS;Coveleskie K;Hammer C;Rappold G;Tillisch K;Bueller JA;Suyenobu B;Jarcho JM;McRoberts JA;Niesler B;Mayer EA
5-HT 3受体（5-HT 3R）拮抗剂可有效治疗肠易激综合征（IBS）患者，并具有抗焦虑作用。它们的治疗效果部分与在预期的内脏疼痛期间减少杏仁核的参与有关。HTR 3A中的单核苷酸多态性（SNP），c. 42 C>T;（C178 T; rs 1062613），与健康受试者（对照组）在情绪面部处理过程中杏仁核反应性的改变有关。我们评估了这种SNP对女性IBS患者和对照组杏仁核对情绪面孔和非情绪刺激的反应性的影响。我们使用功能性磁共振成像测量了54名女性（26名IBS患者，29名对照）在情感匹配范例中的大脑反应。我们研究了HTR 3A c. 42 C>T基因型（C/C与T携带者）和杏仁核和表达高水平5-HT 3R的其他大脑区域的反应。C/C基因型与IBS患者和对照组中更大的焦虑症状相关，并且在情绪和非情绪条件下杏仁核的激活增加。在IBS患者中，C/C基因型与更高的症状评分相关;与其他C/C基因型受试者相比，C/C基因型IBS患者的杏仁核对非情绪刺激的反应增加。无论诊断如何，c. HTR 3A中的42 C>T多态性与T携带者状态相比，与情绪和非情绪任务中焦虑和杏仁核反应性增加相关。这种多态性与IBS症状的严重程度相关。虽然这种基因型不足以诊断IBS，但它与症状的严重程度有关。
5-HT3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. Their therapeutic effects are related, in part, to reducing amygdala engagement during expected visceral pain. A single nucleotide polymorphism (SNP) in HTR3A, c.-42C>T;(C178T; rs1062613), is associated with altered reactivity of the amygdala during emotional face processing in healthy subjects (controls). We evaluated the influence of this SNP on amygdala reactivity to emotional faces and non-emotional stimuli in female patients with IBS and controls. We measured brain responses during an affect-matching paradigm in 54 women (26 with IBS, 29 controls) using functional magnetic resonance imaging. We examined associations between HTR3A c.-42C>T genotype (C/C vs. T carrier) and responses in amygdala and other regions of brain that expressed high levels of 5-HT3R. The C/C genotype was associated with greater anxiety symptoms in patients with IBS and controls and increased activation of the amygdala under emotional and non-emotional conditions. Among patients with IBS, the C/C genotype was associated with greater symptom ratings; a subset of IBS patients with the C/C genotype had increased amygdala responses to non-emotional stimuli, compared to other subjects with C/C genotype. Regardless of diagnosis, the C/C genotype of the c.-42C>T polymorphism in HTR3A, compared to T carrier status, is associated with increased anxiety and amygdala responsiveness during emotional and non-emotional tasks. This polymorphism was associated with severity of IBS symptoms. Although this genotype is not sufficient for diagnosis of IBS, it is associated with severity of symptoms.
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影响因子：
4.3
作者：
Goecke, Tamme W.;Ekici, Arif B.;Fasching, Peter A.
通讯作者：
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影响因子：
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作者：
KILPATRICK, GJ;JONES, BJ;TYERS, MB
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5-HT3受体 - 结构与功能之间的关系。
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Mayer, EA
影响因子：
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作者：
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