Aerobic fitness and cognitive function in midlife: an association mediated by plasma insulin.
Aerobic fitness and cognitive function in midlife: an association mediated by plasma insulin.
复制标题
中年有氧健身和认知功能：血浆胰岛素介导的缔合。
DOI：
10.1007/s11011-013-9431-1
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发表时间：
2013-12
影响因子：
3.6
通讯作者：
Haley, Andreana P.
中科院分区：
文献类型：
--
作者：
Tarumi, Takashi;Gonzales, Mitzi M.;Fallow, Bennett;Nualnim, Nantinee;Lee, Jeongseok;Tanaka, Hirofumi;Haley, Andreana P.
中年胰岛素抵抗增加老年痴呆症的风险。相反，习惯性有氧运动是改善胰岛素抵抗的既定策略，这可能会转化为更好的认知结果。探讨血浆胰岛素在心肺适能和认知功能关系中的作用。58名成年人完成了血浆胰岛素水平、最大耗氧量（VO 2 max）和神经心理测试表现的评估。耐力训练的受试者表现出比久坐受试者更好的认知结果（总复合z评分：0.21±0.08 vs-0.26 ± 0.10，P=0.001）和更低的血浆胰岛素浓度（12.6±0.6 vs 21.3±1.5 ulU/mL，P<0.001）。较高的VO 2 max与较高的记忆能力（β=0.37，P=0.01）和较低的血浆胰岛素水平（β=-0.68，P<0.001）显著相关。当排除血浆胰岛素的间接影响后，VO 2 max与记忆成绩的显著相关性消失（β=0.24，P=0.19）。健身相关的认知增强可能至少部分地由血浆胰岛素水平介导。
Insulin resistance in midlife increases the risk of dementia in late-life. In contrast, habitual aerobic exercise is an established strategy to ameliorate insulin resistance which may translate into better cognitive outcome. To determine the role of plasma insulin in mediating the relation between cardiorespiratory fitness and cognitive function. Fifty-eight adults completed assessments of plasma insulin levels, maximal oxygen consumption (VO2max), and neuropsychological test performance. Endurance-trained subjects demonstrated better cognitive outcome (total composite z-score: 0.21±0.08 versus -0.26±0.10, P=0.001) and lower concentrations of plasma insulin (12.6±0.6 versus 21.3±1.5 ulU/mL, P<0.001) than sedentary subjects. Greater VO2max was significantly associated with higher memory performance (β=0.37, P=0.01) and lower plasma insulin levels (β=-0.68, P<0.001). The significant association between VO2max and memory performance was abolished when the indirect effect of plasma insulin was statistically removed (β=0.24, P=0.19). Fitness-related cognitive enhancement may be mediated, at least in part, by plasma insulin levels.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
--
作者：
BROZINICK, JT;ETGEN, GJ;IVY, JL
通讯作者：
IVY, JL
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
120.7
作者：
Mayer-Davis, EJ;D'Agostino, R;Bergman, RN
通讯作者：
Bergman, RN
影响因子：
8.2
作者：
Colcombe, S;Kramer, AF
通讯作者：
Kramer, AF