The Prognostic Value of CD206 in Solid Malignancies: A Systematic Review and Meta-Analysis.
The Prognostic Value of CD206 in Solid Malignancies: A Systematic Review and Meta-Analysis.
复制标题
DOI：
10.3390/cancers13143422
复制
发表时间：
2021-07-08
期刊：
影响因子：
5.2
通讯作者：
Huvenne W
中科院分区：
文献类型：
--
作者：
Debacker JM;Gondry O;Lahoutte T;Keyaerts M;Huvenne W
先天免疫细胞在肿瘤微环境（TME）中的作用，更具体地说是肿瘤相关巨噬细胞（TAM）的存在，在诊断为恶性肿瘤的患者的预后和治疗中变得越来越重要。本系统回顾和荟萃分析的目的是评估表达 CD206 的 TAM（巨噬细胞的一个亚类）的潜在预后价值，之前曾提出 TAM 对患者的预后产生负面影响。我们鉴定了 27 篇手稿，描述了 CD206 在 14 种不同肿瘤类型的患者预后中的作用。尽管结果存在很大的异质性，但我们发现 TME 中表达 CD206 的 TAM 增加的患者的总体生存率和无病生存率明显较差。因此，表达 CD206 的 TAM 可用作诊断为实体恶性肿瘤的患者的预后标志物。实体癌中表达 CD206 的肿瘤相关巨噬细胞的增加被认为与多种恶性肿瘤的较差结果相关，但已发表的结果相互矛盾。我们按照系统评价和荟萃分析声明的首选报告项目进行了可重复的系统评价和荟萃分析，以提供更多证据来证实或拒绝这一假设。系统地搜索了 Embase、Web of Science 和 MEDLINE 数据库以查找符合条件的手稿。共有 27 篇论文研究了 CD206 对 14 种不同肿瘤类型的预后影响。荟萃分析显示对总生存期（OS）和无病生存期（DFS）有显着影响。虽然无进展生存期 (PFS) 和疾病特异性生存期 (DSS) 没有显着差异，但向阴性生存期的转变与 CD206 表达增加相关。由于肿瘤类型不同，不同肿瘤类型之间存在较大的异质性。肝细胞癌和胃癌的亚组分析显示没有异质性，这与两组 OS 的显着负面影响相关。当前的系统评价显示，表达 CD206 的巨噬细胞的存在增加是诊断为实体癌的患者 OS 和 DFS 的显着负面预后生物标志物。由于荟萃分析中包含了一组异质的肿瘤类型，因此结果不能一概而论。然而，这些结果可用于进一步引导后续研究，以验证 CD206 在个体肿瘤类型和治疗方法中的具体预后价值。
The role of innate immune cells in the tumor microenvironment (TME), more specifically the presence of the tumor associated macrophages (TAMs), is becoming more important in the prognosis and treatment of patients diagnosed with malignancies. The aim of this systematic review and meta-analysis was to assess the potential prognostic value of CD206-expressing TAMs, a subclass of macrophages, which were previously proposed to negatively impact the patient’s prognosis. We identified 27 manuscripts describing the role of CD206 in patient prognosis for 14 different tumor types. Despite a large heterogeneity in the results, we identified a significantly worse overall and disease-free survival for patients with increased CD206-expressing TAMs in the TME. The use of CD206-expressing TAMs could therefore be used as a prognostic marker in patients diagnosed with solid malignancies. An increased presence of CD206-expressing tumor associated macrophages in solid cancers was proposed to be associated with worse outcomes in multiple types of malignancies, but contradictory results are published. We performed a reproducible systematic review and meta-analysis to provide increased evidence to confirm or reject this hypothesis following the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The Embase, Web of Science, and MEDLINE-databases were systematically searched for eligible manuscripts. A total of 27 papers studying the prognostic impact of CD206 in 14 different tumor types were identified. Meta-analyses showed a significant impact on the overall survival (OS) and disease-free survival (DFS). While no significant differences were revealed in progression-free survival (PFS) and disease-specific survival (DSS), a shift towards negative survival was correlated with increased CD206-expresion. As a result of the different tumor types, large heterogeneity was present between the different tumor types. Subgroup analysis of hepatocellular carcinoma and gastric cancers revealed no heterogeneity, associated with a significant negative impact on OS in both groups. The current systematic review displays the increased presence CD206-expressing macrophages as a significant negative prognostic biomarker for both OS and DFS in patients diagnosed with solid cancers. Because a heterogenous group of tumor types was included in the meta-analysis, the results cannot be generalized. These results can, however, be used to further lead follow-up research to validate the specific prognostic value of CD206 in individual tumor types and therapeutic approaches.
登录
查看更多内容
DOI：
10.1002/path.5093
发表时间：
2018-08
期刊：
The Journal of pathology
影响因子：
--
作者：
Enninga EAL;Chatzopoulos K;Butterfield JT;Sutor SL;Leontovich AA;Nevala WK;Flotte TJ;Markovic SN
通讯作者：
Markovic SN
基于肿瘤免疫微环境的免疫表型允许对阴茎癌患者进行无人监督的分层。
影响因子：
5.2
作者：
Chu, Chengbiao;Yao, Kai;Cao, Yun
通讯作者：
Cao, Yun
影响因子：
2
作者：
Liu, Deng-Rui;Guan, Quan-Lin;Kang, Hong-Xia
通讯作者：
Kang, Hong-Xia
影响因子：
3.7
作者：
Le Page C;Marineau A;Bonza PK;Rahimi K;Cyr L;Labouba I;Madore J;Delvoye N;Mes-Masson AM;Provencher DM;Cailhier JF
通讯作者：
Cailhier JF
白细胞介素 6 通过 STAT3 激活诱导 M2 巨噬细胞分化，与胃癌进展相关
影响因子：
5.8
作者：
Fu, Xiao-Long;Duan, Wei;Zhao, Yong-Liang
通讯作者：
Zhao, Yong-Liang