Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection.
Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection.
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DOI：
10.1021/acs.nanolett.6b04865
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发表时间：
2017-03-08
期刊：
影响因子：
10.8
通讯作者：
Conolly SM
中科院分区：
文献类型：
--
作者：
Yu EY;Bishop M;Zheng B;Ferguson RM;Khandhar AP;Kemp SJ;Krishnan KM;Goodwill PW;Conolly SM
癌症仍然是全世界死亡的主要原因之一。生物医学成像在癌症管理的各个阶段都发挥着至关重要的作用。医生通常需要根据空间分辨率、灵敏度、对比度、可及性、成本和安全性之间的复杂权衡，为每种临床表现选择理想的诊断成像方式。磁粒子成像 (MPI) 是一种新兴的示踪成像方式，可检测超顺磁性氧化铁 (SPIO) 纳米粒子示踪剂，具有高图像对比度（零组织背景信号）、高灵敏度 (200 nM Fe)、线性定量和零信号深度衰减。 MPI 的安全性还在于它使用安全的、在某些情况下甚至是经过临床批准的示踪剂并且无电离辐射。卓越的对比度、灵敏度、安全性以及对身体任何部位进行成像的能力为 MPI 在癌症成像方面带来了巨大的希望。在这项研究中，我们首次展示了使用 MPI 进行全身示踪剂施用的体内癌症成像。在这里，长循环的 MPI 定制的 SPIO 被创建并静脉注射给荷瘤大鼠。肿瘤以高达 50 的肿瘤与背景比突出显示。肿瘤中的纳米颗粒动力学也得到了很好的评价，最初在肿瘤边缘吸收，在 6 小时达到峰值吸收，并最终在 48 小时后清除。最后，我们通过体内区室拟合证明了 MPI 的定量性质。
Cancer remains one of the leading causes of death worldwide. Biomedical imaging plays a crucial role in all phases of cancer management. Physicians often need to choose the ideal diagnostic imaging modality for each clinical presentation based on complex trade-offs between spatial resolution, sensitivity, contrast, access, cost, and safety. Magnetic particle imaging (MPI) is an emerging tracer imaging modality that detects superparamagnetic iron oxide (SPIO) nanoparticle tracer with high image contrast (zero tissue background signal), high sensitivity (200 nM Fe) with linear quantitation and zero signal depth attenuation. MPI is also safe in that it uses safe, in some cases even clinically approved tracers and no ionizing radiation. The superb contrast, sensitivity, safety, and ability to image anywhere in the body lends MPI great promise for cancer imaging. In this study, we show for the first time the use of MPI for in vivo cancer imaging with systemic tracer administration. Here, long circulating MPI-tailored SPIOs were created and administered intravenously in tumor bearing rats. The tumor was highlighted with tumor-to-background ratio of up to 50. The nanoparticle dynamics in the tumor was also well appreciated, with initial wash-in on the tumor rim, peak uptake at 6 hours, and eventual clearance beyond 48 hours. Lastly, we demonstrate the quantitative nature of MPI through compartmental fitting in vivo.
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DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
3.7
作者：
Antonelli, Antonella;Sfara, Carla;Magnani, Mauro
通讯作者：
Magnani, Mauro
影响因子：
6.7
作者：
Khandhar AP;Keselman P;Kemp SJ;Ferguson RM;Goodwill PW;Conolly SM;Krishnan KM
通讯作者：
Krishnan KM
影响因子：
3.4
作者：
Hong H;Yang Y;Zhang Y;Cai W
通讯作者：
Cai W
影响因子：
45.3
作者：
Frangioni, John V.
通讯作者：
Frangioni, John V.