Roles for growth factors in cancer progression.
Roles for growth factors in cancer progression.
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DOI：
10.1152/physiol.00045.2009
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Yarden Y
中科院分区：
文献类型：
--
作者：
Witsch E;Sela M;Yarden Y
在生理条件下，细胞从其组织环境接收主要以多肽生长因子形式的决定命运的信号。这些细胞外信号的整合是组织稳态的基础。虽然偏离稳态和肿瘤起始是由致癌突变而不是生长因子引起的，但后者是肿瘤进展的所有后续步骤的主要调节剂，即克隆扩增、跨越组织屏障的侵袭、血管生成和远处小生境的定殖。在这里，我们讨论了相关的生长因子家族，它们在肿瘤生物学中的作用，以及各自的下游信号通路。重要的是，影响这些途径的癌症相关激活突变通常部分缓解肿瘤对生长因子的依赖。另一方面，生长因子经常参与对治疗方案的抗性的演变，这将多肽因子的作用扩展到肿瘤进展的非常晚期，并为癌症治疗提供了机会。
Under physiological conditions, cells receive fate-determining signals from their tissue surroundings, primarily in the form of polypeptide growth factors. Integration of these extracellular signals underlies tissue homeostasis. Although departure from homeostasis and tumor initiation are instigated by oncogenic mutations rather than by growth factors, the latter are the major regulators of all subsequent steps of tumor progression, namely clonal expansion, invasion across tissue barriers, angiogenesis, and colonization of distant niches. Here, we discuss the relevant growth factor families, their roles in tumor biology, as well as the respective downstream signaling pathways. Importantly, cancer-associated activating mutations that impinge on these pathways often relieve, in part, the reliance of tumors on growth factors. On the other hand, growth factors are frequently involved in evolvement of resistance to therapeutic regimens, which extends the roles for polypeptide factors to very late phases of tumor progression and offers opportunities for cancer therapy.
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