Longitudinal features of stir bright signal in FSHD1
Longitudinal features of stir bright signal in FSHD1
复制标题
FSHD1 中搅拌亮信号的纵向特征
作者：
S. Friedman;S. Poliachik;Randolph K. Otto;G. Carter;C. Budech;T. Bird;Daniel G. Miller;D. Shaw
简介：肌肉磁共振成像显示常染色体显性面肩肱肌营养不良症（FSHD1）的短tau‐反转恢复（STIR）亮度提示活动性炎症/损伤。我们测量了这种潜在疾病生物标志物的纵向稳定性/进展。方法：9名受试者在2年内接受了小腿MRI成像。两名放射科医生评估了定性肌肉变化。结果：在3/9的受试者中，小腿肌肉在时间1表现出中度/重度STIR高强度，并在2年后发展为脂肪替代（时间2）。在其余受试者中，中度/重度肌肉STIR异常，当存在时，在两次检查之间是一致的。轻度的STIR+升高在两次检查之间的模式大致相似。结论：中度/重度STIR高信号通常预示着2年的脂肪替代。是否需要更长的时间来观察某些受试者的肌肉变性和脂肪替代仍有待探讨。中国机械工程学报，2014,31 (2):557 - 557
Introduction: Magnetic resonance imaging of muscle shows short tau‐inversion recovery (STIR) brightness in autosomal dominant facioscapulohumeral muscular dystrophy (FSHD1) suggestive of active inflammation/injury. We measured the longitudinal stability/progression of this potential disease biomarker. Methods: Nine subjects underwent calf MRI imaging over 2 years. Two radiologists evaluated qualitative muscle changes. Results: In 3/9 subjects, calf muscles demonstrated moderate/severe STIR hyperintensity at Time 1 that had progressed to fatty replacement 2 years later (Time 2). In the remaining subjects, moderate/severe muscle STIR abnormalities, when present, were consistent between exams. Mild STIR+ elevations had roughly similar patterns between exams. Conclusions: Moderate/severe STIR hyperintensities often foreshadow fatty replacement over a 2‐year interval. Whether longer time courses are required to observe muscle degeneration and fatty replacement in some subjects remains to be explored. Muscle Nerve 49: 257–260, 2014
影响因子：
13.6
作者：
van der Maarel SM;Tawil R;Tapscott SJ
通讯作者：
Tapscott SJ