Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake.
Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake.
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DOI：
10.1016/j.physbeh.2017.08.002
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发表时间：
2019-05-01
影响因子：
2.9
通讯作者：
Szumlinski KK
中科院分区：
文献类型：
--
作者：
Quadir SG;Guzelian E;Palmer MA;Martin DL;Kim J;Szumlinski KK
Alcohol use disorders, affective disorders and their comorbidity are sexually dimorphic in humans. However, it is difficult to disentangle the interactions between subject factors influencing alcohol sensitivity in studies of humans. Herein, we combined murine models of unpredictable, chronic, mild stress (UCMS) and voluntary binge-drinking to examine for sex differences in the interactions between prior histories of excessive ethanol-drinking and stress upon ethanol-induced changes in motor behavior and subsequent drinking. In Experiment 1, female mice were insensitive to the UCMS-induced increase in ethanol-induced locomotion and ethanol intake under continuous alcohol-access. Experiment 2 revealed interactions between ethanol dose and sex (females > males), binge-drinking history (water > ethanol), and UCMS history (UCMS > controls), with no additive effect of a sequential prior history of both binge drinking and UCMS observed. We also observed an interaction between UCMS history and sex for righting recovery. UCMS history potentiated subsequent binge-drinking in water controls of both sexes and in male binge-drinking mice. Conversely, a prior binge-drinking history increased subsequent ethanol intake in females only, irrespective of prior UCMS history. In Experiment 3, a concurrent history of binge-drinking and UCMS did not alter ethanol intake, nor did it influence the ethanol dose-locomotor response function, but it did augment alcohol-induced sedation and reduced subsequent alcohol intake over that produced by binge-drinking alone. Thus, the subject factors of biological sex, prior stressor history and prior binge-drinking history interact in complex ways in mice to impact sensitivity to alcohol’s motor-stimulating, -incoordinating and intoxicating effects, as well as to influence subsequent heavy drinking.
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影响因子：
4.2
作者：
Becker, Jill B.;McClellan, Michele L.;Reed, Beth Glover
通讯作者：
Reed, Beth Glover
影响因子：
3.2
作者：
Blednov, Yuri A.;Black, Mendy;Harris, R. Adron
通讯作者：
Harris, R. Adron
DOI：
10.1111/j.1530-0277.2001.tb02269.x
发表时间：
2001-05-01
影响因子：
3.2
作者：
Anthenelli, RM;Maxwell, RA;Hauger, R
通讯作者：
Hauger, R
影响因子：
3.7
作者：
Blednov YA;Benavidez JM;Black M;Leiter CR;Osterndorff-Kahanek E;Johnson D;Borghese CM;Hanrahan JR;Johnston GA;Chebib M;Harris RA
通讯作者：
Harris RA
影响因子：
3.6
作者：
Cronise, K;Finn, DA;Crabbe, JC
通讯作者：
Crabbe, JC