Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells
Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells
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人类免疫缺陷病毒 1 型和 2 型的病毒蛋白 R 对于淋巴细胞中的复制和致细胞病变性是必不可少的
作者：
D. Dedera;Wen Hu;N. V. Heyden;Lee Ratner
病毒蛋白R （VPR）在人类免疫缺陷病毒1型和2型（HIV-1和HIV-2）中是保守的。为了评估其功能，我们在HIV-1和HIV-2的vpr编码区构建了预测表达截断vpr产物的突变。传染病毒由每个原病毒克隆产生，与相应的亲本原病毒克隆相比表现出相似的复制动力学和细胞致病性。
Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar replication kinetics and cytopathogenicity when compared with the corresponding parental proviral clone.
影响因子：
56.9
作者：
HENDERSON, LE;SOWDER, RC;OROSZLAN, S
通讯作者：
OROSZLAN, S