Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women.
Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women.
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女性生殖因素与痛风之间的关系：一项针对100万绝经后妇女的全国性人群队列研究
DOI：
10.1186/s13075-021-02701-w
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发表时间：
2021-12-16
影响因子：
4.9
通讯作者：
Kim H
中科院分区：
文献类型：
--
作者：
Eun Y;Kim IY;Han K;Lee KN;Lee DY;Shin DW;Kang S;Lee S;Cha HS;Koh EM;Lee J;Kim H
以往的研究表明，痛风的发病率和危险因素因性别而异。然而，很少有研究已经做了生殖因素和痛风之间的关联。我们对一个全国性的绝经后妇女群体进行了分析，以确定生殖因素与痛风发病率之间是否存在关联。共有1，076，378名年龄在40-69岁之间的绝经后妇女参加了2009年的国家健康筛查。结果是痛风事件的发生，这是使用索赔数据库中的ICD-10痛风代码（M10）定义的。采用考克斯比例风险模型进行分析，并根据体重指数（BMI）和是否存在慢性肾脏疾病（CKD）进行分层分析。平均随访时间为8.1年，痛风发病病例为64，052例（发病率为7.31/1000人-年）。月经初潮晚，绝经早，生育期短与痛风的高风险有关。未观察到产次与痛风发病率之间的相关性。口服避孕药（OC）和激素替代疗法（HRT）的使用与痛风风险增加有关。在高BMI组中，生殖因素与痛风之间的关联没有统计学意义。在CKD组中，OC和HRT的使用对痛风的影响不显著。较短的内源性雌激素暴露与痛风的高风险相关。相反，暴露于外源性雌激素如OC和HRT与痛风风险增加有关。在线版本包含补充材料，可通过10.1186/s13075-021-02701-w获得。
Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted an analysis of a large nationwide population-based cohort of postmenopausal women to determine whether there is an association between reproductive factors and the incidence of gout. A total of 1,076,378 postmenopausal women aged 40–69 years who participated in national health screenings in 2009 were included in the study. The outcome was the occurrence of incident gout, which was defined using the ICD-10 code of gout (M10) in the claim database. Cox proportional hazard models were used for the analyses and stratified analyses according to body mass index (BMI) and the presence/absence of chronic kidney disease (CKD) were performed. The mean follow-up duration was 8.1 years, and incident cases of gout were 64,052 (incidence rate 7.31 per 1000 person-years). Later menarche, earlier menopause, and a shorter reproductive span were associated with a high risk of gout. No association between parity and gout incidence was observed. Use of oral contraceptives (OC) and hormone replacement therapy (HRT) were associated with an increased risk of gout. The association between reproductive factors and gout was not statistical significant in the high BMI group. The effects of OC and HRT usage on gout were not significant in the CKD group. Shorter exposure to endogenous estrogen was associated with a high risk of gout. Conversely, exposure to exogenous estrogen such as OC and HRT was associated with an increased risk of gout. The online version contains supplementary material available at 10.1186/s13075-021-02701-w.
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影响因子：
8.8
作者：
Clavel-Chapelon, F
通讯作者：
Clavel-Chapelon, F
影响因子：
5.6
作者：
Simon, JA;Lin, F;Bittner, V
通讯作者：
Bittner, V
DOI：
10.1152/ajprenal.00029.2004
发表时间：
2004-07-01
影响因子：
4.2
作者：
Ljubojevic, M;Herak-Kramberger, CM;Sabolic, I
通讯作者：
Sabolic, I
影响因子：
8.8
作者：
Jeon, Keun Hye;Shin, Dong Wook;Cho, Jong Ho
通讯作者：
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影响因子：
4.6
作者：
Eun Y;Jeon KH;Han K;Kim D;Kim H;Lee J;Lee DY;Yoo JE;Shin DW
通讯作者：
Shin DW