Menopausal factors and risk of seropositive rheumatoid arthritis in postmenopausal women: a nationwide cohort study of 1.36 million women.
Menopausal factors and risk of seropositive rheumatoid arthritis in postmenopausal women: a nationwide cohort study of 1.36 million women.
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DOI：
10.1038/s41598-020-77841-1
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发表时间：
2020-11-27
影响因子：
4.6
通讯作者：
Shin DW
中科院分区：
文献类型：
--
作者：
Eun Y;Jeon KH;Han K;Kim D;Kim H;Lee J;Lee DY;Yoo JE;Shin DW
在以往的文献中，关于类风湿关节炎（RA）的发展，女性生殖因素已被描述为保护因素，危险因素，或无关，导致不一致的结果。本研究的目的是探讨女性生殖因素对血清阳性RA发病率的影响。使用了韩国国民健康保险服务数据的一个大型基于人群的回顾性队列。纳入了2009年参加心血管和乳腺癌筛查的绝经后女性，并对其进行随访，直至血清阳性RA诊断、死亡或2018年12月31日。采用多变量校正的考克斯比例风险模型评估生殖因素与血清阳性RA事件之间的关系。在1，357，736名绝经后妇女中，6056名妇女被诊断为血清阳性RA，发病率为54.16例/10万人年。除激素替代治疗（HRT）外，生殖因素与血清阳性RA发病率无显著相关性。使用HRT ≥ 5年的绝经后妇女与血清阳性RA事件的aHR高于从未使用者（aHR 1.25; 95% CI 1.09-1.44）。每天饮酒量少于30克（aHR 0.80; 95% CI 0.74-0.87），定期体力活动（aHR 0.90; 95% CI 0.84-0.97），糖尿病（aHR 0.85; 95% CI 0.78-0.93）和癌症（aHR 0.77; 95% CI 0.64-0.92）与血清阳性RA的风险较低相关。大多数女性生殖因素并没有显着影响绝经后妇女血清阳性RA的发展。只有HRT与血清阳性RA风险的小幅但显著增加相关。
In previous literature regarding development of rheumatoid arthritis (RA), female reproductive factors have been described as protective factors, risk factors, or irrelevant, leading to inconsistent results. The aim of this study was to investigate the effect of female reproductive factors on the incidence of seropositive RA. A large population-based retrospective cohort of the National Health Insurance Service data in South Korea was used. Postmenopausal women who participated in both cardiovascular and breast cancer screening in 2009 were included and followed until date of seropositive RA diagnosis, death, or December 31, 2018. Multivariable-adjusted Cox proportional hazards model was used to assess the association between reproductive factors and incident seropositive RA. Of 1,357,736 postmenopausal women, 6056 women were diagnosed with seropositive RA, and the incidence rate was 54.16 cases/100,000 person-years. Reproductive factors other than hormone replacement therapy (HRT) were not significantly associated with seropositive RA incidence. Postmenopausal women who used HRT ≥ 5 years were associated with a higher aHR of incident seropositive RA than never-users (aHR 1.25; 95% CI 1.09–1.44). Alcohol consumption less than 30 g per day (aHR 0.80; 95% CI 0.74–0.87), regular physical activity (aHR 0.90; 95% CI 0.84–0.97), diabetes mellitus (aHR 0.85; 95% CI 0.78–0.93), and cancer (aHR 0.77; 95% CI 0.64–0.92) were associated with lower risk of seropositive RA. Most female reproductive factors did not significantly affect the development of seropositive RA in postmenopausal women. Only HRT is associated with a small but significant increase in risk of seropositive RA.
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影响因子：
--
作者：
Myasoedova, Elena;Crowson, Cynthia S.;Kremers, Hilal Maradit;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
--
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Myasoedova, Elena;Michet, Clement J.;Ernste, Floranne C.;Warrington, Kenneth J.;Davis, John M., III;Hunder, Gene G.;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
7.7
作者：
Lee, Juneyoung;Lee, Ji Sung;Kim, KeeWhan
通讯作者：
Kim, KeeWhan
DOI：
10.1097/gme.0b013e3182a14372
发表时间：
2013-09-01
影响因子：
2.7
作者：
Beydoun, Hind A.;el-Amin, Rawan;Archer, David F.
通讯作者：
Archer, David F.
影响因子：
2.5
作者：
Chen, Qi;Jin, Zhichao;He, Jia
通讯作者：
He, Jia