BK viral enhancer element and a human cellular homolog.
BK viral enhancer element and a human cellular homolog.
复制标题
BK 病毒增强子元件和人类细胞同源物。
作者：
N. Rosenthal;M. Kress;P. Gruss;G. Khoury
对两种关系密切的灵长类乳头状病毒，猴病毒40(SV40)和人BK病毒(BKV)进行比较，发现SV40中唯一广泛分歧的区域，即DNA复制起点附近的串联序列，负责促进早期基因的表达。这项研究证明了BKV中类似重复区域的类似增强子功能。BKV和SV40增强子序列的不同提示它们可能是在SV40和BKV分化后获得的。从人类基因组中克隆的与BKV串联重复序列同源的一个基因座已被证明在哺乳动物细胞中作为低水平的增强子元件发挥作用。这些数据支持病毒增强子序列可能在进化上与宿主细胞序列相关的假设。
Comparison of two closely related primate papovaviruses, simian virus 40 (SV40) and human BK virus (BKV), reveals that the only region of extensive divergence, the tandem sequences adjacent to the origins of DNA replication, is responsible in SV40 for enhancing early gene expression. This study demonstrates a similar enhancer function for the analogous repeated region in BKV. The dissimilarity in sequence of the BKV and SV40 enhancer elements suggests that they may have been acquired since SV40 and BKV diverged. A locus cloned from the human genome homologous to the BKV tandem repeats has been shown to function as low level enhancer element in mammalian cells. These data support the hypothesis that viral enhancer sequences may be evolutionarily related to host cell sequences.
DOI：
10.1172/jci111638
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Knowler,WC;Pettitt,DJ;Vasquez,B;Rotwein,PS;Andreone,TL;Permutt,MA
通讯作者：
Permutt,MA
鼠逆转录病毒长末端重复中的元件增强了胸苷激酶基因的稳定转化。
影响因子：
14.9
作者：
Jolly,DJ;Esty,AC;Subramani,S;Friedmann,T;Verma,IM
通讯作者：
Verma,IM