Endothelin-1 impairs glucose transporter trafficking via a membrane-based mechanism.
Endothelin-1 impairs glucose transporter trafficking via a membrane-based mechanism.
复制标题
Endothelin-1 通过基于膜的机制损害葡萄糖转运蛋白的运输。
DOI：
10.1002/jcb.20687
复制
发表时间：
2006
影响因子：
4
通讯作者：
Elmendorf,JeffreyS
中科院分区：
文献类型：
--
作者：
Strawbridge,AndrewB;Elmendorf,JeffreyS
Endothelin‐1 (ET‐1) disrupts insulin‐regulated glucose transporter GLUT4 trafficking. Since the negative consequence of chronic ET‐1 exposure appears to be independent of signal disturbance along the insulin receptor substrate‐1/phosphatidylinositol (PI) 3‐kinase (PI3K)/Akt‐2 pathway of insulin action, we tested if ET‐1 altered GLUT4 regulation engaged by osmotic shock, a PI3K‐independent stimulus that mimics insulin action. Regulation of GLUT4 by hyperosmotic stress was impaired by ET‐1. Because of the mutual disruption of both insulin‐ and hyperosmolarity‐stimulated GLUT4 translocation, we tested whether shared signaling and/or key phosphatidylinositol 4,5‐bisphosphate (PIP2)‐regulated cytoskeletal events of GLUT4 trafficking were targets of ET‐1. Both insulin and hyperosmotic stress signaling to Cbl were impaired by ET‐1. Also, plasma membrane PIP2and cortical actin levels were reduced in cells exposed to ET‐1. Exogenous PIP2, but not PI 3,4,5‐bisphosphate, restored actin structure, Cbl activation, and GLUT4 translocation. These data show that ET‐1‐induced PIP2/actin disruption impairs GLUT4 trafficking elicited by insulin and hyperosmolarity. In addition to showing for the first time the important role of PIP2‐regulated cytoskeletal events in GLUT4 regulation by stimuli other than insulin, these studies reveal a novel function of PIP2/actin structure in signal transduction. J. Cell. Biochem. 97: 849–856, 2006. © 2005 Wiley‐Liss, Inc.
登录
查看更多内容
影响因子：
--
作者：
BETZ, AL;CSEJTEY, J;GOLDSTEIN, GW
通讯作者：
GOLDSTEIN, GW
脑内皮细胞的分离和表征：形态学和酶活性
影响因子：
4.7
作者：
Stuart K. Williams;John F. Gillis;M. A. Matthews;Roger C. Wagnert;M. Bitensky
通讯作者：
M. Bitensky
大脑皮质微血管：胰岛素敏感组织。
DOI：
--
发表时间：
1982
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
D. Pillion;J. Haskell;E. Meezan
通讯作者：
E. Meezan
高血压、衰老和实验性糖尿病中大鼠脑微血管的脂肪酸氧化。
影响因子：
5.3
作者：
N. Morisaki;Y. Saito;A. Kumagai
通讯作者：
A. Kumagai
糖尿病引起的大鼠脑微血管葡萄糖代谢的改变。
DOI：
10.1152/ajpendo.1984.247.4.e462
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
McCall,AL;Gould,JB;Ruderman,NB
通讯作者：
Ruderman,NB