Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review.
Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review.
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DOI:
10.4251/wjgo.v13.i1.1
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发表时间:
2021-01-15
影响因子:
3
通讯作者:
Merchant JL
中科院分区:
文献类型:
--
作者:
Farshidpour M;Ahmed M;Junna S;Merchant JL
Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.
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