Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review.

Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review.
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DOI:
10.4251/wjgo.v13.i1.1
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发表时间:
2021-01-15
影响因子:
3
通讯作者:
Merchant JL
Merchant JL
中科院分区:
医学4区
文献类型:
--
作者:
Farshidpour M;Ahmed M;Junna S;Merchant JL

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胃肠道(GI)癌是世界范围内最常见的恶性肿瘤之一,发病率和死亡率都很高。骨髓源性抑制细胞(MDSC)是肿瘤微环境(TME)的主要组成部分。MDSC促进癌前细胞的转化,并在肿瘤生长和转移中发挥作用。此外,在GI恶性肿瘤患者中,MDSC可导致T细胞和自然杀伤细胞的抑制。因此,更好地理解MDSC在TME中的作用和作用机制将有助于开发新的免疫靶向疗法。
Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.
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