Prognostic impact of a new score using neutrophil-to-lymphocyte ratios in the serum and malignant pleural effusion in lung cancer patients.
Prognostic impact of a new score using neutrophil-to-lymphocyte ratios in the serum and malignant pleural effusion in lung cancer patients.
复制标题
使用中性粒细胞与淋巴细胞比例在肺癌患者血清和恶性胸腔积液中使用新评分的预后影响。
DOI：
10.1186/s12885-017-3550-8
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发表时间：
2017-08-22
期刊：
影响因子：
3.8
通讯作者：
Lee HL
中科院分区：
文献类型：
--
作者：
Lee YS;Nam HS;Lim JH;Kim JS;Moon Y;Cho JH;Ryu JS;Kwak SM;Lee HL
Various studies have reported that the neutrophil-to-lymphocyte ratio in the serum (sNLR) may serve as a cost-effective and useful prognostic factor in patients with various cancer types. However, no study has reported the prognostic impact of the NLR in malignant pleural effusion (MPE). To address this gap, we investigated the clinical impact of NLR as a prognostic factor in MPE (mNLR) and a new scoring system that use NLRs in the serum and MPE (smNLR score) in lung cancer patients. We retrospectively reviewed all of the patients who were diagnosed with lung cancer and who presented with pleural effusion. To maintain the quality of the study, only patients with malignant cells in the pleural fluid or tissue were included. The patients were classified into three smNLR score groups, and clinical variables were investigated for their correlation with survival. In all, 158 patients were classified into three smNLR score groups as follows: 84 (53.2%) had a score of 0, 58 (36.7%) had a score of 1, and 16 (10.1%) had a score of 2. In a univariate analysis, high sNLR, mNLR, and increments of the smNLR score were associated with shorter overall survival (p < 0.001, p = 0.004, and p < 0.001, respectively); moreover, age, Eastern Cooperative Oncology Group performance status (ECOG PS), histology, M stage, hemoglobin level, albumin level, and calcium level were significant prognostic factors. A multivariable analysis confirmed that ECOG PS (p < 0.001), histology (p = 0.001), and smNLR score (p < 0.012) were independent predictors of overall survival. The new smNLR score is a useful and cost-effective prognostic factor in lung cancer patients with MPE. Although further studies are required to generalize our results, this information will benefit clinicians and patients in determining the most appropriate therapy for patients with MPE. The online version of this article (doi:10.1186/s12885-017-3550-8) contains supplementary material, which is available to authorized users.
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影响因子：
158.5
作者：
Lynch, TJ;Bell, DW;Haber, DA
通讯作者：
Haber, DA
影响因子：
10
作者：
Clive AO;Kahan BC;Hooper CE;Bhatnagar R;Morley AJ;Zahan-Evans N;Bintcliffe OJ;Boshuizen RC;Fysh ET;Tobin CL;Medford AR;Harvey JE;van den Heuvel MM;Lee YC;Maskell NA
通讯作者：
Maskell NA
影响因子：
3.4
作者：
Cedres, S.;Torrejon, D.;Felip, E.
通讯作者：
Felip, E.
影响因子：
10.3
作者：
Pine, Sharon R.;Mechanic, Leah E.;Harris, Curtis C.
通讯作者：
Harris, Curtis C.
影响因子：
8.8
作者：
Kang, M. H.;Go, S-I;Song, H-N;Lee, A.;Kim, S-H;Kang, J-H;Jeong, B-K;Kang, K. M.;Ling, H.;Lee, G-W
通讯作者：
Lee, G-W