The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer.
The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer.
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DOI：
10.1038/bjc.2014.317
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发表时间：
2014-07-29
影响因子：
8.8
通讯作者：
Lee, G-W
中科院分区：
文献类型：
--
作者：
Kang, M. H.;Go, S-I;Song, H-N;Lee, A.;Kim, S-H;Kang, J-H;Jeong, B-K;Kang, K. M.;Ling, H.;Lee, G-W
中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）是各种类型癌症的预后因素。在本研究中，我们评估了NLR和PLR与接受标准治疗的小细胞肺癌（SCLC）患者预后的关系。我们回顾性分析了2006年7月至2013年10月在庆尚道国立大学医院地区癌症中心和昌原三星医院诊断为SCLC并接受铂基化疗的患者。总共评估了187例患者。与低NLR（<4）相比，诊断时的高NLR（大于或等于4）与较差的表现状态、晚期和较低的反应率相关。中位总生存期（OS）和无进展生存期（PFS）在高nlr组更差（高vs低，11.17 vs 9.20个月，P=0.019和6.90 vs 5.49个月，P=0.005）。相比之下，诊断时PLR与OS或PFS无关（P=0.467和P=0.205）。在多因素分析中，分期、乳酸脱氢酶和诊断时NLR是OS和PFS的独立预后因素。NLR很容易测量，反映了SCLC的预后。未来的前瞻性研究有必要证实我们的结果。
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment. We retrospectively reviewed patients who were diagnosed with SCLC and treated with platinum-based chemotherapy between July 2006 and October 2013 in Gyeongsang National University Hospital Regional Cancer Center and Changwon Samsung Hospital. In total, 187 patients were evaluated. Compared with low NLR (<4), high NLR (⩾4) at diagnosis was associated with poor performance status, advanced stage, and lower response rate. Median overall survival (OS) and progression-free survival (PFS) were worse in the high-NLR group (high vs low, 11.17 vs 9.20 months, P=0.019 and 6.90 vs 5.49 months, P=0.005, respectively). In contrast, PLR at diagnosis was not associated with OS or PFS (P=0.467 and P=0.205, respectively). In multivariate analysis, stage, lactate dehydrogenase, and NLR at diagnosis were independent prognostic factors for OS and PFS. NLR is easily measurable and reflects the SCLC prognosis. A future prospective study is warranted to confirm our results.
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影响因子：
3.8
作者：
Kim DK;Oh SY;Kwon HC;Lee S;Kwon KA;Kim BG;Kim SG;Kim SH;Jang JS;Kim MC;Kim KH;Han JY;Kim HJ
通讯作者：
Kim HJ
影响因子：
4.4
作者：
Keane, MP;Belperio, JA;Strieter, RM
通讯作者：
Strieter, RM
影响因子：
7.3
作者：
Berger-Achituv S;Brinkmann V;Abed UA;Kühn LI;Ben-Ezra J;Elhasid R;Zychlinsky A
通讯作者：
Zychlinsky A
影响因子：
11.2
作者：
Acuff, HB;Carter, KJ;Matrisian, LM
通讯作者：
Matrisian, LM
影响因子：
3.4
作者：
Cedres, S.;Torrejon, D.;Felip, E.
通讯作者：
Felip, E.