Altered immune responses in rhesus macaques co-infected with SIV and Plasmodium cynomolgi: an animal model for coincident AIDS and relapsing malaria.
Altered immune responses in rhesus macaques co-infected with SIV and Plasmodium cynomolgi: an animal model for coincident AIDS and relapsing malaria.
复制标题
与SIV和疟原虫共同感染的恒河猕猴中的免疫反应改变了：一种用于复合艾滋病和复发疟疾的动物模型。
DOI：
10.1371/journal.pone.0007139
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发表时间：
2009-09-23
期刊：
影响因子：
3.7
通讯作者：
Cogswell FB
中科院分区：
文献类型：
--
作者：
Koehler JW;Bolton M;Rollins A;Snook K;deHaro E;Henson E;Rogers L;Martin LN;Krogstad DJ;James MA;Rice J;Davison B;Veazey RS;Prabhu R;Amedee AM;Garry RF;Cogswell FB
Dual epidemics of the malaria parasite Plasmodium and HIV-1 in sub-Saharan Africa and Asia present a significant risk for co-infection in these overlapping endemic regions. Recent studies of HIV/Plasmodium falciparum co-infection have reported significant interactions of these pathogens, including more rapid CD4+ T cell loss, increased viral load, increased immunosuppression, and increased episodes of clinical malaria. Here, we describe a novel rhesus macaque model for co-infection that supports and expands upon findings in human co-infection studies and can be used to identify interactions between these two pathogens. Five rhesus macaques were infected with P. cynomolgi and, following three parasite relapses, with SIV. Compared to macaques infected with SIV alone, co-infected animals had, as a group, decreased survival time and more rapid declines in markers for SIV progression, including peripheral CD4+ T cells and CD4+/CD8+ T cell ratios. The naïve CD4+ T cell pool of the co-infected animals was depleted more rapidly than animals infected with SIV alone. The co-infected animals also failed to generate proliferative responses to parasitemia by CD4+ and CD8+ T cells as well as B cells while also having a less robust anti-parasite and altered anti-SIV antibody response. These data suggest that infection with both SIV and Plasmodium enhances SIV-induced disease progression and impairs the anti-Plasmodium immune response. These data support findings in HIV/Plasmodium co-infection studies. This animal model can be used to further define impacts of lentivirus and Plasmodium co-infection and guide public health and therapeutic interventions.
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影响因子：
11.8
作者：
Cohen, C;Karstaedt, A;Crewe-Brown, H
通讯作者：
Crewe-Brown, H
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3.8
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French, N;Nakiyingi, J;Gilks, CF
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Gilks, CF
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64.8
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HILL, AVS;ELVIN, J;WHITTLE, HC
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WHITTLE, HC
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Ahmed, R
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168.9
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Kublin, JG;Patnaik, P;Molyneux, ME
通讯作者：
Molyneux, ME