The entirely carbohydrate immunogen Tn-PS A1 induces a cancer cell selective immune response and cytokine IL-17.
The entirely carbohydrate immunogen Tn-PS A1 induces a cancer cell selective immune response and cytokine IL-17.
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完全碳水化合物TN-PS A1诱导癌细胞选择性免疫反应和细胞因子IL-17。
DOI：
10.1007/s00262-012-1205-9
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发表时间：
2012-04
影响因子：
5.8
通讯作者：
Andreana, Peter R.
中科院分区：
文献类型：
--
作者：
De Silva, Ravindra A.;Appulage, Dananjaya K.;Pietraszkiewicz, Halina;Bobbitt, Kevin R.;Media, Joe;Shaw, JiaJiu;Valeriote, Fred A.;Andreana, Peter R.
将肿瘤相关碳水化合物抗原/半抗原Alpensen-nouveau（Tn; α-D-GalpNAc-ONH 2）与来自嗜酸性厌氧菌脆弱拟杆菌ATCC 25285/NCTC 9343的两性离子荚膜多糖PS A1偶联，用于开发完全碳水化合物的癌症疫苗构建体并探测免疫原性。该通信公开了鼠抗Tn IgG 3抗体结合并识别展示Tn半抗原的人肿瘤细胞。此外，来自用Tn-PS A1免疫小鼠的血清含有细胞因子白细胞介素17（IL-17 A），已知其具有抗肿瘤功能，并且代表与用抗PS A1血清获得的IL-2和IL-6谱的显著差异。
The tumor-associated carbohydrate antigen/hapten Thomsen-nouveau (Tn; α-D-GalpNAc-ONH2) was conjugated to a zwitterionic capsular polysaccharide, PS A1, from commensal anaerobe Bacteroides fragilis ATCC 25285/NCTC 9343 for the development of an entirely carbohydrate cancer vaccine construct and probed for immunogenicity. This communication discloses that murine anti-Tn IgG3 antibodies both bind to and recognize human tumor cells that display the Tn hapten. Furthermore, the sera from immunization of mice with Tn-PS A1 contain cytokine interleukin 17 (IL-17A), which is known to possess anti-tumor function and represents a striking difference to an IL-2, and IL-6 profile obtained with anti-PS A1 sera.
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补体激活有选择地增强高亲和力抗雄激素自身抗体的IgG2b和IgG3同种型的致病性。
影响因子：
15.3
作者：
Azeredo da Silveira, Samareh;Kikuchi, Shuichi;Fossati-Jimack, Liliane;Moll, Thomas;Saito, Takashi;Verbeek, J Sjef;Botto, Marina;Walport, Mark J;Carroll, Michael;Izui, Shozo
通讯作者：
Izui, Shozo
影响因子：
64.8
作者：
Esplugues, Enric;Huber, Samuel;Gagliani, Nicola;Hauser, Anja E.;Town, Terrence;Wan, Yisong Y.;O'Connor, William, Jr.;Rongvaux, Anthony;Van Rooijen, Nico;Haberman, Ann M.;Iwakura, Yoichiro;Kuchroo, Vijay K.;Kolls, Jay K.;Bluestone, Jeffrey A.;Herold, Kevan C.;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
影响因子：
15.3
作者：
Avery, OT;Goebel, WF
通讯作者：
Goebel, WF
影响因子：
4.3
作者：
Suzuki, M;Suzuki, M;Fukuda, M
通讯作者：
Fukuda, M
影响因子：
2.8
作者：
Fernsten, P;Shaw, M;Winfield, J
通讯作者：
Winfield, J