PPARβ/δ: Linking Metabolism to Regeneration.
PPARβ/δ: Linking Metabolism to Regeneration.
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DOI：
10.3390/ijms19072013
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发表时间：
2018-07-10
影响因子：
5.6
通讯作者：
Engel FB
中科院分区：
文献类型：
--
作者：
Magadum A;Engel FB
与普遍认为再生是一种罕见的事件，主要发生在简单的生物体中相反，再生的能力在动物界广泛分布。然而，再生的效率和程度差异很大。人类可以从失血以及骨骼和肝脏等组织的损伤中恢复过来。然而，对心脏和大脑的损害无法逆转，从而导致恐惧。因此，人们对了解自然发生的再生的分子机制并将这一知识应用于修复人体器官非常感兴趣。在再生过程中，损伤激活的免疫细胞诱导伤口愈合、细胞外基质重塑、迁移、去分化和/或增殖，从而导致体细胞或干细胞的分化。抗炎反应会阻止再生过程，而再生过程以组织重塑结束，从而达到最初的功能状态。值得注意的是，这些过程中的许多都与糖酵解增强有关。因此，过氧化物酶体增殖物激活受体β/δ被认为是促进哺乳动物再生的一个有希望的靶点。本文综述了PPARβ/δ在创伤愈合和再生相关过程中的研究现状。
In contrast to the general belief that regeneration is a rare event, mainly occurring in simple organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the efficiency and extent of regeneration varies greatly. Humans can recover from blood loss as well as damage to tissues like bone and liver. Yet damage to the heart and brain cannot be reversed, resulting in scaring. Thus, there is a great interest in understanding the molecular mechanisms of naturally occurring regeneration and to apply this knowledge to repair human organs. During regeneration, injury-activated immune cells induce wound healing, extracellular matrix remodeling, migration, dedifferentiation and/or proliferation with subsequent differentiation of somatic or stem cells. An anti-inflammatory response stops the regenerative process, which ends with tissue remodeling to achieve the original functional state. Notably, many of these processes are associated with enhanced glycolysis. Therefore, peroxisome proliferator-activated receptor (PPAR) β/δ—which is known to be involved for example in lipid catabolism, glucose homeostasis, inflammation, survival, proliferation, differentiation, as well as mammalian regeneration of the skin, bone and liver—appears to be a promising target to promote mammalian regeneration. This review summarizes our current knowledge of PPARβ/δ in processes associated with wound healing and regeneration.
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