Adherence to the HPV vaccine dosing intervals and factors associated with completion of 3 doses.
Adherence to the HPV vaccine dosing intervals and factors associated with completion of 3 doses.
复制标题
DOI：
10.1542/peds.2010-0812
复制
发表时间：
2011-01
期刊：
影响因子：
8
通讯作者：
Kahn JA
中科院分区：
文献类型：
--
作者：
Widdice LE;Bernstein DI;Leonard AC;Marsolo KA;Kahn JA
本研究的目的是确定 (1) 遵守人乳头瘤病毒四价疫苗的免疫计划和 (2) 与完成 3 剂系列相关的因素。这是对学术医疗中心的健康信息记录的回顾性审查。样本包括四价疫苗上市后 2 年内开始接种疫苗的所有 9 至 26 岁女性患者。估计多变量逻辑回归模型以确定与 7 个月和 12 个月内完成 3 剂系列的关联。在开始接种人乳头瘤病毒四价疫苗的3297名女性患者中，67%的人自认为是黑人，29%的人自认为是白人。不到 3% 的疫苗剂量比推荐时间更早接种，但超过 50% 的疫苗剂量延迟接种。 7 个月时完成率为 14%，12 个月时完成率为 28%。 7 个月内完成的独立预测因素包括白人与黑人种族（比值比 [OR]：2.04 [95% 置信区间 (CI)：1.64 –2.56]；P < .001）、使用需要每 3 个月肌内注射的避孕措施（OR：1.53 [95% CI：1.12-1.95]；P < .001）以及私人保险与公共保险（OR：1.31 [95% CI：1.06 –1.63]；P < .05）。年龄和临床类型不是完成的独立预测因素。遵守建议的间隔时间和疫苗系列的完成率较低。与白人患者相比，黑人患者的疫苗接种完成率较低，这引发了人们的担忧，即疫苗接种完成率的差异可能会加剧宫颈癌现有的差异。
The objectives of this study were to determine (1) adherence to the immunization schedule for the human papillomavirus quadrivalent vaccine and (2) factors associated with completion of the 3-dose series. This was a retrospective review of health information records from an academic medical center. The sample included all 9- to 26-year-old female patients who initiated vaccination within 2 years after quadrivalent vaccine availability. Multivariable logistic regression models were estimated to determine associations with completion of the 3-dose series within 7 and 12 months. Among the 3297 female patients who initiated vaccination with human papillomavirus quadrivalent vaccine, 67% self-identified as black and 29% self-identified as white. Fewer than 3% of vaccine doses were received earlier than recommended, but >50% of doses were received late. Completion rates were 14% by 7 months and 28% by 12 months. Independent predictors of completion by 7 months included white versus black race (odds ratio [OR]: 2.04 [95% confidence interval (CI): 1.64 –2.56]; P < .001), use of contraception that required intramuscular injections every 3 months (OR: 1.53 [95% CI: 1.12–1.95]; P < .001), and private versus public insurance (OR: 1.31 [95% CI: 1.06 –1.63]; P < .05). Age and clinic type were not independent predictors of completion. Adherence to recommended intervals and completion of the vaccine series were low. Lower rates of completion in black patients compared with white patients raises concern that disparities in vaccine completion could exacerbate existing disparities in cervical cancer.
登录
查看更多内容
影响因子：
8
作者：
Halsey, NA;Moulton, LH;Krause, DS
通讯作者：
Krause, DS
影响因子：
8
作者：
Block, Stan L.;Nolan, Terry;Reisinger, Keith S.
通讯作者：
Reisinger, Keith S.
影响因子：
8
作者：
Irwin, Charles E., Jr.;Adams, Sally H.;Newacheck, Paul W.
通讯作者：
Newacheck, Paul W.
影响因子：
8.9
作者：
Chao, Chun;Velicer, Chrstine;Jacobsen, Steven J.
通讯作者：
Jacobsen, Steven J.
影响因子：
6.4
作者：
JILG, W;SCHMIDT, M;DEINHARDT, F
通讯作者：
DEINHARDT, F