Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults.
Parasagittal dural space and cerebrospinal fluid (CSF) flow across the lifespan in healthy adults.
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DOI：
10.1186/s12987-022-00320-4
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发表时间：
2022-03-21
影响因子：
7.3
通讯作者：
Donahue MJ
中科院分区：
文献类型：
--
作者：
Hett K;McKnight CD;Eisma JJ;Elenberger J;Lindsey JS;Considine CM;Claassen DO;Donahue MJ
最近的研究提出了脑实质代谢废物的替代脑脊液（CSF）清除途径。这些通路的一个基本但相对未被充分探索的组成部分是上矢状窦周围的解剖区域，该区域已被证明与跨蛛网膜分子通道相关。这种所谓的矢状旁硬脑膜（PSD）空间可能作为人类类淋巴回路的远端颅内组成部分发挥着重要的生理作用，但我们对这个空间如何随着正常衰老和颅内大量液体运输而变化的了解仍然存在根本差距。我们重新参数化了 MRI 方法，使用 PSD 空间的高分辨率成像和通过脑导水管的流量的相差测量来评估人体 CSF 循环，以测试 PSD 空间的体积测量值 (1) 与通过脑导水管的 CSF 流量 (mL/s) 直接相关，以及 (2) 随着年龄的增长而增加的假设。多模态 3-Tesla MRI 应用于健康参与者（n = 62；年龄范围 = 20-83 岁）的整个成人寿命，其中通过导水管的脑脊液流的相差评估与用于 PSD 容量的非对比 T1 加权和 T2 加权 MRI 配对。 PSD 体积是使用最近验证的神经网络算法提取的。应用非参数回归模型来评估PSD体积与组织体积和年龄的横截面关系，以及单独评估PSD体积与CSF流量的关系（显着性标准：两侧p<0.05）。观察到与正常衰老相关的 PSD 体积显着增大（p< 0.001，Spearman’s- = 0.6）、CSF 体积（p < 0.001，Spearman’s- = 0.6）和通过 Sylvius 导水管的最大 CSF 流量（顺行和逆行，p< 0.001）。 PSD 体积的升高与灰质或白质组织体积没有显着相关。研究结果与 PSD 体积随着年龄和脑脊液流量的增加而增加是一致的。研究结果强调了使用机器学习和非对比 MRI 在人体中无创量化 PSD 体积的可行性。此外，研究结果表明，PSD 体积随着年龄的增长而增加，并与脑脊液体积和双向流动相关。报告的值应该为 PSD 体积如何随年龄调整提供有用的规范范围，这将作为与神经退行性疾病患者进行比较的必要先决条件。在线版本包含可在 10.1186/s12987-022-00320-4 获取的补充材料。
Recent studies have suggested alternative cerebrospinal fluid (CSF) clearance pathways for brain parenchymal metabolic waste products. One fundamental but relatively under-explored component of these pathways is the anatomic region surrounding the superior sagittal sinus, which has been shown to have relevance to trans-arachnoid molecular passage. This so-called parasagittal dural (PSD) space may play a physiologically significant role as a distal intracranial component of the human glymphatic circuit, yet fundamental gaps persist in our knowledge of how this space changes with normal aging and intracranial bulk fluid transport. We re-parameterized MRI methods to assess CSF circulation in humans using high resolution imaging of the PSD space and phase contrast measures of flow through the cerebral aqueduct to test the hypotheses that volumetric measures of PSD space (1) are directly related to CSF flow (mL/s) through the cerebral aqueduct, and (2) increase with age. Multi-modal 3-Tesla MRI was applied in healthy participants (n = 62; age range = 20–83 years) across the adult lifespan whereby phase contrast assessments of CSF flow through the aqueduct were paired with non-contrasted T1-weighted and T2-weighted MRI for PSD volumetry. PSD volume was extracted using a recently validated neural networks algorithm. Non-parametric regression models were applied to evaluate how PSD volume related to tissue volume and age cross-sectionally, and separately how PSD volume related to CSF flow (significance criteria: two-sided p < 0.05). A significant PSD volume enlargement in relation to normal aging (p < 0.001, Spearman’s- = 0.6), CSF volume (p < 0.001, Spearman’s- = 0.6) and maximum CSF flow through the aqueduct of Sylvius (anterograde and retrograde, p < 0.001) were observed. The elevation in PSD volume was not significantly related to gray or white matter tissue volumes. Findings are consistent with PSD volume increasing with age and bulk CSF flow. Findings highlight the feasibility of quantifying PSD volume non-invasively in vivo in humans using machine learning and non-contrast MRI. Additionally, findings demonstrate that PSD volume increases with age and relates to CSF volume and bi-directional flow. Values reported should provide useful normative ranges for how PSD volume adjusts with age, which will serve as a necessary pre-requisite for comparisons to persons with neurodegenerative disorders. The online version contains supplementary material available at 10.1186/s12987-022-00320-4.
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影响因子：
7.7
作者：
Absinta M;Ha SK;Nair G;Sati P;Luciano NJ;Palisoc M;Louveau A;Zaghloul KA;Pittaluga S;Kipnis J;Reich DS
通讯作者：
Reich DS
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
1.6
作者：
Choi, Hyuk Jin;Cho, Chang Won;Cha, Jae Hun
通讯作者：
Cha, Jae Hun
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y