Progress and prospects for stem cell engineering.
Progress and prospects for stem cell engineering.
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DOI：
10.1146/annurev-chembioeng-061010-114105
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发表时间：
2011
影响因子：
8.4
通讯作者：
Schaffer DV
中科院分区：
文献类型：
--
作者：
Ashton RS;Keung AJ;Peltier J;Schaffer DV
干细胞具有自我更新和分化成多种成体组织细胞类型的能力，因此具有巨大的生物医学潜力。研究人员和工程师越来越多地开发新的发现技术、理论方法和细胞培养系统，以研究控制干细胞命运的微环境线索和细胞信号事件。其中许多技术有助于对微环境信号和细胞内信号网络以及将这些信号处理为细胞命运决定的机器进行高通量研究。随着我们对干细胞调节的总体经验知识的增长，系统和计算生物学方法的理论建模对于发展我们从复杂数据中分析和提取干细胞调节的重要概念特征的能力已经并将继续发挥重要作用。基于这些知识体系，干细胞工程师将继续开发可预测地控制干细胞命运的技术，最终目标是能够准确且经济地扩大这些系统的规模，以实现干细胞疗法的临床级生产。
Stem cells offer tremendous biomedical potential owing to their abilities to self-renew and differentiate into cell types of multiple adult tissues. Researchers and engineers have increasingly developed novel discovery technologies, theoretical approaches, and cell culture systems to investigate microenvironmental cues and cellular signaling events that control stem cell fate. Many of these technologies facilitate high-throughput investigation of microenvironmental signals and the intracellular signaling networks and machinery processing those signals into cell fate decisions. As our aggregate empirical knowledge of stem cell regulation grows, theoretical modeling with systems and computational biology methods has and will continue to be important for developing our ability to analyze and extract important conceptual features of stem cell regulation from complex data. Based on this body of knowledge, stem cell engineers will continue to develop technologies that predictably control stem cell fate with the ultimate goal of being able to accurately and economically scale up these systems for clinical-grade production of stem cell therapeutics.
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影响因子：
4.3
作者：
Agrawal S;Archer C;Schaffer DV
通讯作者：
Schaffer DV
影响因子：
14
作者：
Carpenedo, Richard L.;Bratt-Leal, Andrs M.;Marklein, Ross A.;Seaman, Scott A.;Bowen, Nathan J.;McDonald, John F.;McDevitt, Todd C.
通讯作者：
McDevitt, Todd C.
影响因子：
4
作者：
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通讯作者：
Wang, Zack Z.
影响因子：
4.9
作者：
Carpenedo, Richard L.;Seaman, Scott A.;McDevitt, Todd C.
通讯作者：
McDevitt, Todd C.
影响因子：
64.8
作者：
Chang, Hannah H.;Hemberg, Martin;Huang, Sui
通讯作者：
Huang, Sui