Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect.

Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect.
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糖尿病中的β细胞功能障碍:胰岛微环境是一种不寻常的嫌疑犯。

DOI:
10.1007/s00125-020-05186-5
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发表时间:
2020-10
期刊:
影响因子:
8.2
通讯作者:
Landsman L
Landsman L
中科院分区:
医学1区
文献类型:
--
作者:
Almaça J;Caicedo A;Landsman L

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不同组织中的细胞,包括胰腺中的内分泌细胞,生活在富含细胞和非细胞成分的复杂微环境中。与其微环境的复杂相互作用决定了大多数细胞特性,例如它们的功能、结构和大小,并维持组织稳态。胰岛由浸入细胞外基质中的内分泌细胞、血管细胞和免疫细胞组成。虽然β细胞的内在特性已经被广泛研究,但我们对它们与周围环境相互作用的理解直到最近才开始揭开面纱。在这里,我们回顾了目前关于胰岛细胞和非细胞成分之间相互作用的研究,以及这些成分在 β 细胞生理学和病理生理学中发挥的作用。尽管β细胞衰竭是糖尿病的关键病理机制,但其原因还远未完全阐明。因此,我们提出胰岛生态位的有害改变是导致β细胞衰竭的潜在潜在机制。总之,本综述强调胰岛的功能取决于其所有组成部分。
Cells in different tissues, including endocrine cells in the pancreas, live in complex microenvironments that are rich in cellular and acellular components. Intricate interactions with their microenvironment dictate most cellular properties, such as their function, structure and size, and maintain tissue homeostasis. Pancreatic islets are populated by endocrine, vascular and immune cells that are immersed in the extracellular matrix. While the intrinsic properties of beta cells have been vastly investigated, our understanding of their interactions with their surroundings has only recently begun to unveil. Here, we review current research on the interplay between the islet cellular and acellular components, and the role these components play in beta cell physiology and pathophysiology. Although beta cell failure is a key pathomechanism in diabetes, its causes are far from being fully elucidated. We, thus, propose deleterious alterations of the islet niche as potential underlying mechanisms contributing to beta cell failure. In sum, this review emphasises that the function of the pancreatic islet depends on all of its components.
DOI: 10.2337/db16-1477
发表时间: 2017-05
期刊: Diabetes
影响因子: 7.7
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发表时间: 2017-09
期刊: Diabetes, obesity & metabolism
影响因子: --
作者:
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通讯作者: Powers AC
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