Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice.
Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice.
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DOI：
10.1016/j.neurobiolaging.2011.05.001
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发表时间：
2012-08
影响因子：
4.2
通讯作者：
Waters J
中科院分区：
文献类型：
--
作者：
Wykes R;Kalmbach A;Eliava M;Waters J
Amyloid-β protein (Aβ) is thought to play a central pathogenic role in Alzheimer’s disease. Aβ can impair synaptic transmission, but little is known about the effects of Aβ on intrinsic cellular properties. Here we compared the cellular properties of CA1 hippocampal pyramidal neurons in acute slices from pre-plaque transgenic (Tg+) CRND8 mice and wild-type (Tg−) littermates. CA1 pyramidal neurons from Tg+ mice had narrower action potentials with faster decays than neurons from Tg− littermates. Action potential-evoked intracellular Ca2+ transients in the apical dendrite were smaller in Tg+ than Tg− neurons. Resting calcium concentration was higher in Tg+ than Tg− neurons. The difference in action potential waveform was eliminated by low concentrations of tetraethylammonium ions and of 4-aminopyridine, implicating a fast delayed-rectifier potassium current. Consistent with this suggestion, there was a small increase in immunoreactivity for Kv3.1b in stratum radiatum in Tg+ mice. These changes in intrinsic properties may affect information flow through the hippocampus and contribute to the behavioral deficits observed in mouse models and patients with early-stage Alzheimer’s disease.
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影响因子：
3.4
作者：
GOLDSTEIN, SS;RALL, W
通讯作者：
RALL, W
DOI：
10.1073/pnas.0600948103
发表时间：
2006-03-28
影响因子：
11.1
作者：
Jacobsen, JS;Wu, CC;Bloom, FE
通讯作者：
Bloom, FE
影响因子：
25
作者：
Chapman, PF;White, GL;Hsiao, KK
通讯作者：
Hsiao, KK
DOI：
10.1073/pnas.96.6.3228
发表时间：
1999-03-16
影响因子：
11.1
作者：
Hsia, AY;Masliah, E;Mucke, L
通讯作者：
Mucke, L
DOI：
10.1016/j.bbrc.2005.10.169
发表时间：
2005-12-30
影响因子：
3.1
作者：
Chen, C
通讯作者：
Chen, C