Linked open drug data for pharmaceutical research and development.

Linked open drug data for pharmaceutical research and development.
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DOI:
10.1186/1758-2946-3-19
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发表时间:
2011-05-16
影响因子:
8.6
通讯作者:
Stephens S
Stephens S
中科院分区:
化学2区
文献类型:
--
作者:
Samwald M;Jentzsch A;Bouton C;Kallesøe CS;Willighagen E;Hajagos J;Marshall MS;Prud'hommeaux E;Hassenzadeh O;Pichler E;Stephens S

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网上有大量关于药物的信息。数据来源包括药物化学结果、药物对基因表达的影响以及临床试验中药物的结果。这些数据通常没有连接在一起,这降低了获得见解的容易程度。链接开放药物数据(LODD)是万维网联盟(W3C)卫生保健和生命科学兴趣小组(HCLS IG)的一个工作组。LODD调查了有关药物的公开数据,创建了数据集的关联数据表示,并确定了一旦数据集连接起来就可以回答的有趣的科学和商业问题。该工作组为在关联数据表示中公开数据的最佳实践提供了建议。在本文中,我们介绍了LODD过去和正在进行的工作,并讨论了关联数据作为制药研发数据共享基础的日益重要性。
There is an abundance of information about drugs available on the Web. Data sources range from medicinal chemistry results, over the impact of drugs on gene expression, to the outcomes of drugs in clinical trials. These data are typically not connected together, which reduces the ease with which insights can be gained. Linking Open Drug Data (LODD) is a task force within the World Wide Web Consortium's (W3C) Health Care and Life Sciences Interest Group (HCLS IG). LODD has surveyed publicly available data about drugs, created Linked Data representations of the data sets, and identified interesting scientific and business questions that can be answered once the data sets are connected. The task force provides recommendations for the best practices of exposing data in a Linked Data representation. In this paper, we present past and ongoing work of LODD and discuss the growing importance of Linked Data as a foundation for pharmaceutical R&D data sharing.
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