Safety of one method of sputum induction in asthmatic subjects.
Safety of one method of sputum induction in asthmatic subjects.
复制标题
哮喘受试者中一种痰诱导方法的安全性。
DOI：
10.1164/ajrccm.156.1.9610114
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发表时间：
1997
影响因子：
24.7
通讯作者：
J. Fahy
中科院分区：
文献类型：
--
作者：
H. Wong;J. Fahy
为了评估哮喘受试者痰诱导的安全性，我们对来自我们机构的78名受试者的351次痰诱导的数据进行了回顾性分析。诱导痰方案包括基线FEV 1、沙丁胺醇180 μ g预处理、15 min后支气管扩张剂后肺功能测定、诱导程序本身（吸入3%生理盐水20 min）和诱导痰后肺功能测定。我们发现诱导痰通常耐受良好，尽管有些受试者出现喘息和呼吸困难。总体而言，78例受试者中有11例（14%）在首次诱导痰期间FEV 1较支气管扩张剂后基线下降≥ 20%（“过度支气管收缩”）（范围：-20至-69%）;无受试者发生需要住院或急诊治疗的难治性支气管收缩。54例基线使用支气管扩张剂前FEV 1> 80%的受试者中只有1例（1.9%）出现过度支气管收缩，而24例基线FEV 1 <或= 80%预测值的受试者中有10例（42%）出现过度支气管收缩。诱导痰液中FEV 1的变化与基线使用支气管扩张剂前FEV1%预测值、基线使用支气管扩张剂后FEV1%预测值、乙酰甲胆碱PC 20和诱导痰中嗜酸性粒细胞百分比显著相关。我们的结论是，180 μ g沙丁胺醇不能防止所有接受痰诱导的哮喘受试者的过度支气管收缩，尤其是在基线FEV 1较低的哮喘受试者中。哮喘受试者在诱导痰期间应定期监测肺功能，以监测过度支气管收缩。
To assess the safety of sputum induction in asthmatic subjects, we conducted a retrospective review of data from 351 sputum inductions in 78 subjects from our institution. The sputum induction protcol consisted of baseline FEV1, pretreatment with albuterol 180 micrograms, postbronchodilator spirometry 15 min later, the induction procedure itself (inhalation of 3% saline for 20 min), and postsputum induction spirometry. We found that sputum induction was usually well tolerated, although some subjects developed wheeze and dyspnea. Overall, 11 of the 78 subjects (14%) had a fall in FEV1 of > or = 20% from the postbronchodilator baseline ("excessive bronchoconstriction") during their first sputum induction (range: -20 to -69%); no subject developed refractory bronchoconstriction requiring hospitalization or emergency room treatment. Only one of the 54 subjects (1.9%) with a baseline prebronchodilator FEV1 > 80% had excessive bronchoconstriction, whereas 10 of the 24 subjects (42%) whose baseline FEV1 was < or = 80% predicted did so. The change in FEV1 during sputum induction was significantly correlated with the baseline prebronchodilator FEV1% predicted, the baseline postbronchodilator FEV1% predicted, the PC20 for methacholine, and the percentage of eosinophils in induced sputum. We conclude that 180 micrograms albuterol does not prevent excessive bronchoconstriction in all asthmatic subjects undergoing sputum induction, especially in asthmatic subjects with a low baseline FEV1. Pulmonary function should be monitored regularly during sputum induction in asthmatic subjects to monitor for excessive bronchoconstriction.
渗透激活的嗜碱性粒细胞和人肺肥大细胞释放的组胺和花生四烯酸代谢物的解离。
DOI：
10.1164/ajrccm/141.4_pt_1.960
发表时间：
1990
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Eggleston,PA;Kagey-Sobotka,A;Proud,D;AdkinsonJr,NF;Lichtenstein,LM
通讯作者：
Lichtenstein,LM